TNF R I, /TNFRSF1A, Human

简介：
TNF Receptor Type I, is also known as TNF R-p55/p60 and TNFRSF1A. It is a type I transmembrane protein member of the TNF receptor superfamily. It is expressed in most cell types. Binding of either TNF-α or TNF-β to TNF-R1 initiates a signal transduction pathway that results in the activation of the transcription factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells, induce apoptosis. TNF-R1 is essential for proper development of lymph node germinal centers and Peyer’s patches and for combating intracellular pathogens such as Listeria. It is stored in the Golgi and translocates to the cell surface following proinflammatory stimuli.

I 型 TNF 受体也称为 TNF R-p55/p60 和 TNFRSF1A。 它是 TNF 受体超家族的 I 型跨膜蛋白成员。 它在大多数细胞类型中表达。 TNF-α 或 TNF-β 与 TNF-R1 的结合启动信号转导途径，导致转录因子 NF-κB 的激活，其靶基因参与炎症反应的调节，并且在某些细胞中， 诱导细胞凋亡。 TNF-R1对于淋巴结生发中心和派尔斑的正常发育以及对抗李斯特菌等细胞内病原体至关重要。 它储存在高尔基体中并在促炎刺激后转移到细胞表面。
别名：Soluble Tumor Necrosis Factor type I, TNFRSF1A, TNFAR, TNF-R55, TNFR60, p55, CD120a
性状描述：
Species：……………………………Human
Source：……………………………CHO
Measured Molecular Weight：……28~35 kDa, observed by reducing SDS-PAGE.
Purity：………………………………> 95% as analyzed by SDS-PAGE.
Formulation：………………………Lyophilized after extensive dialysis against PBS.
Reconstitution：……………………Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level：…………………< 0.2 EU/μg, determined by LAL method.
Sequence：

DSVCPQGKYI HPQNNSICCT KCHKGTYLYN DCPGPGQDTD
CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD
RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE
KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQIE
N
储存条件：
Lyophilized recombinant Human TNF Receptor Type I remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human TNF Receptor Type I should be stable up to 1 week at 4°C or up to 2 months at -20°C.

冻干重组人 TNF 受体 I 型自收到之日起在 -70°C 以下保持稳定长达 6 个月。 重组后，人 TNF 受体 I 型应在 4°C 下稳定长达 1 周或在 -20°C 下长达 2 个月。

运输条件：

2~8℃运输
生物活性：
ED50 < 50 ng/ml, measured in a cell proliferation assay using 929 cells in the presence of 1 ng/ml human TNF-α.
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用途及描述：科研试剂，广泛应用于分子生物学，药理学等科研方面，严禁用于人体。

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