Application: ELISA, IF, WB, IHC
Clonality: Monoclonal
Host: Mouse
Purification: Ig-PG
Background
Advanced Glycation End Product (AGE) is a general term for structures generated in the late stage of non-enzymatic glycation reactions (Millard reactions) between reducing sugars and proteins. AGE accumulation is known to be significantly elevated in age-related diseases such as diabetes and arteriosclerosis.
Nε-(carboxyethyl) lysine (CEL) is generated from protein modification by methylglyoxal (MG). MG is enzymatically derived from the Embden-Meyerhof and polyol pathways, through the degradation of glyceraldehyde-3-phosphate (G3P) (Phillips and Thornalley, 1993). Mclellan et al. (McLellan et al., 1994) demonstrated that plasma MG concentration in insulin-dependent diabetic patients was 7-times higher than in healthy individuals. CEL accumulation increases with age in human lens proteins.
Source: Professor Nagai Ryuji, Tokai University Faculty of Agriculture Department of Biosciences Food Bioregulation Research Laboratory
Product description
| Package Size | 50 µg |
|---|---|
| Form | Liquid (0.1M NaPB, pH7.0, 20 mg/ml BSA, 0.1% Sodium Azide (NaN3 ) added) |
| Concentration | 1 mg/mL |
| Purity | Affinity Purified |
| Host | Rabbit Polyclonal |
| Immunogen | Synthetic phosphopeptide corresponding to residues L(44)S(p)PFYLRPPSF(54)C of human alpha-B Crystallin |
| Specificity | Alpha-B crystallin p45S |
| Cross Reactivity | Bovine, Human, Mouse, Rat |
| Subclass | IgG |
| Storage | Store below -20°C. Avoid freeze-thaw cycles. |