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BSG Human
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Basigin Human Recombinant
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PRO-2516
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Catalogue number
PRO-2516
Synonyms
Basigin isoform 2, 5F7, CD147, EMMPRIN, OK, TCSF, Leukocyte activation antigen M6, OK blood group antigen.
Introduction
Basigin Isoform 2 or BSG is a part of the immunoglobulin superfamily, it is a type 1 transmembrane protein which has a variety of Nand O- glycosylation. BSG has several ligands, such as integrins, cyclophilin proteins Cyp-A & CyP-B. The protein has a crucial role in intercellular recognition, it takes part in many immunologic processes, differentiation and cell development. Also, it regulates numerus cell processes such as production and release of expression of the mono-carboxylate transporter, spermatogenesis, etc. Basigin Isoform 2 promotes invasion, metastasis, growth and survival of malignant cells by producing and releasing matrix metalloproteinases nearby mesenchymal cells and tumor cells.
Basigin Isoform 2或BSG是免疫球蛋白超家族的一部分，它是一种具有多种Nand O-糖基化的1型跨膜蛋白。 BSG 有多种配体，例如整合素、亲环蛋白 Cyp-A 和 CyP-B。 该蛋白质在细胞间识别中起着至关重要的作用，它参与许多免疫过程、分化和细胞发育。 此外，它还调节许多细胞过程，如单羧酸转运蛋白的产生和释放、精子发生等。 Basigin Isoform 2 通过在间充质细胞和肿瘤附近产生和释放基质金属蛋白酶来促进恶性细胞的侵袭、转移、生长和存活 细胞。
Description
BSG produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 428 amino acids and having a molecular mass of 47.5kDa. .
BSG is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 BSG 是单条糖基化多肽链，包含 428 个氨基酸，分子量为 47.5kDa。 .
BSG 在 C 末端用 242 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。
Source
Sf9, Baculovirus cells.
Physical Appearance
Formulation
BSG protein solution contains phosphate buffered saline and 10% glycerol.
Stability
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by -PAGE.
Amino acid sequence
ADPAAGTVFT TVEDLGSKIL LTCSLNDSAT EVTGHRWLKG GVVLKEDALP GQKTEFKVDS DDQWGEYSCV FLPEPMGTAN IQLHGPPRVK AVKSSEHINE GETAMLVCKS ESVPPVTDWA WYKITDSEDK ALMNGSESRF FVSSSQGRSE LHIENLNMEA DPGQYRCNGT SSKGSDQAII
TLRVRSHLAL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG
QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH.