ProSpec,CD21 Human,CD21人重组PRO-2615

Complement receptor type 2, Cr2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor, CD21 antigen, CR2, C3DR, CD21, SLEB9.

CD21 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

CD21 在成熟 B 细胞、滤泡树突细胞上强烈表达，在未成熟胸腺细胞和 T 淋巴细胞上表达较弱。 在 B 细胞个体发育中，CD21 出现在前 B 阶段之后，在外周 B 细胞发育过程中保持不变，并在终末分化为浆细胞时丢失。 在体外刺激 B 细胞后，CD21 的表达也逐渐丧失。 CD21 作为 C3d、C3dg 和 iC3b 补体成分、EBV 和 IFNα 的受体发挥作用。 CD21 与 CD23 结合并与 CD19、CD81 和 Leu13 结合形成一个参与 B 细胞活化的大信号转导复合物。

CD21 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 959 amino acids and having a molecular mass of 105.2kDa.
CD21 is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD21 Human Recombinant 是单条糖基化多肽链，包含 959 个氨基酸，分子量为 105.2kDa。
CD21 在 C 末端与 8 个氨基酸的 His-Tag 融合，并通过专有色谱技术进行纯化。

Sf9, Baculovirus cells.

Sterile Filtered colorless solution.

The CD21 solution contains 10% Glycerol and Phosphate Buffered Saline .

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 95.0% as determined by -PAGE.

ISCGSPPPIL NGRISYYSTP IAVGTVIRYS CSGTFRLIGE KSLLCITKDK VDGTWDKPAP
KCEYFNKYSS CPEPIVPGGY KIRGSTPYRH GDSVTFACKT NFSMNGNKSV WCQANNMWGP
TRLPTCVSVF PLECPALPMI HNGHHTSENV GSIAPGLSVT YSCESGYLLV GEKIINCLSS
GKWSAVPPTC EEARCKSLGR FPNGKVKEPP ILRVGVTANF FCDEGYRLQG PPSSRCVIAG
QGVAWTKMPV CEEIFCPSPP PILNGRHIGN SLANVSYGSI VTYTCDPDPE EGVNFILIGE
STLRCTVDSQ KTGTWSGPAP RCELSTSAVQ CPHPQILRGR MVSGQKDRYT YNDTVIFACM
FGFTLKGSKQ IRCNAQGTWE PSAPVCEKEC QAPPNILNGQ KEDRHMVRFD PGTSIKYSCN
PGYVLVGEES IQCTSEGVWT PPVPQCKVAA CEATGRQLLT KPQHQFVRPD VNSSCGEGYK
LSGSVYQECQ GTIPWFMEIR LCKEITCPPP PVIYNGAHTG SSLEDFPYGT TVTYTCNPGP
ERGVEFSLIG ESTIRCTSND QERGTWSGPA PLCKLSLLAV QCSHVHIANG YKISGKEAPY
FYNDTVTFKC YSGFTLKGSS QIRCKADNTW DPEIPVCEKE TCQHVRQSLQ ELPAGSRVEL
VNTSCQDGYQ LTGHAYQMCQ DAENGIWFKK IPLCKVIHCH PPPVIVNGKH TGMMAENFLY
GNEVSYECDQ GFYLLGEKKL QCRKGHG SWSGPSPQCL RSPPVTRCPN PEVKHGYKLN
KTHSAYSHND IVYVDCNPGF IMNGSRVIRC HTDNTWVPGV PTCIKKAFIG CPPPPKTPNG
NHTGGNIARF SPGMSILYSC DQGYLLVGEA LLLCTHEGTW SQPAPHCKEV NCSSPADMDG
IQKGLEPRKM YQYGAVVTLE CEDGYMLEGS PQSQCQSDHQ WNPPLAVCRS RVEHHHHHH

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