ProSpec,CD276 Human,CD276 人重组PRO-2456

CD276 Molecule, CD276 Antigen, Costimulatory Molecule, B7 Homolog 3, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2.

CD276, belongs to the B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. CD276 is a costimulatory molecule for T cell activation in addition to IFN-gamma production. Furthermore CD276 upregulates BRCC3 expression, preventing DNA defects caused by 5-Fu. CD276 is correlated with TNM stage of NSCLC and act as a potential biomarker for NSCLC-derived MPEs. CD276 inhibits natural-killer mediated cell lysis in tumor cells, and act as a marker for detection of neuroblastoma cells. CD276 is implicated in the development of acute as well as chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. In addition, CD276 provides the placenta & fetus a proper immunological environment during the course of pregnancy.

CD276，属于 T 细胞表达的免疫调节性跨膜糖蛋白 B7 家族。 CD276 是除了 IFN-γ 产生之外的 T 细胞活化的共刺激分子。 此外，CD276 上调 BRCC3 表达，防止由 5-Fu 引起的 DNA 缺陷。 CD276 与 NSCLC 的 TNM 分期相关，可作为 NSCLC 衍生 MPE 的潜在生物标志物。 CD276 抑制肿瘤细胞中自然杀伤剂介导的细胞裂解，并作为检测神经母细胞瘤细胞的标志物。 CD276 与急性和慢性移植排斥的发展以及黏膜表面淋巴细胞活性的调节有关。 此外，CD276 在怀孕期间为胎盘和胎儿提供了适当的免疫环境。

CD276 Human Recombinant  produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 446 amino acids and having a molecular mass of 48.1kDa . CD276 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD276 Human Recombinant 是单条糖基化多肽链，包含 446 个氨基酸，分子量为 48.1kDa。 CD276 在 C 末端用 8 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Sf9, Baculovirus cells.

Sterile filtered colorless solution.

CD276 protein solution contains Phosphate buffered saline and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 90.0% as determined by -PAGE.

LEVQVPEDPV VALVGTDATL CCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FAEGQDQGSA YANRTALFPD LLAQGNASLR LQRVRVADEG SFTCFVSIRD FGSAAVSLQV AAPYSKPSMT LEPNKDLRPG DTVTITCSSY QGYPEAEVFW QDGQGVPLTG NVTTSQMANE QGLFDVHSIL RVVLGANGTY SCLVRNPVLQ QDAHSSVTIT PQRSPTGAVE VQVPEDPVVA LVGTDATLRC SFSPEPGFSL AQLNLIWQLT DTKQLVHSFT EGRDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITCSSYRG YPEAEVFWQD GQGVPLTGNV TTSQMANEQG LFDVHSVLRV VLGANGTYSC LVRNPVLQQD AHGSVTITGQ PMTFPPEALE HHHHHH.

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