ProSpec,CD48 Human,CD48人重组PRO-2462

CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, SLAM family member 2, SLAMF2, Signaling lymphocytic activation molecule 2, TCT.1.

CD48, is a GPI-linked protein which belongs to the CD2 family of immunoglobulin superfamily molecules. CD48 is capable to transduce signals and can likewise trigger signaling through CD2 or 2B4. CD48 to CD2 interactions advocate T cell activation and class replacing to IgG2a in B cells. In addition, high affinity of CD48 to 2B4, interactions may either promote or inhibit NK cell as well as cytotoxic T cell activation.  CD48 does not contain a transmembrane domain, though it is held at the cell surface by a GPI anchor through a C-terminal domain which possibly split to produce a soluble form of the receptor.

CD48 是一种 GPI 连接蛋白，属于 CD2 家族的免疫球蛋白超家族分子。 CD48 能够转导信号，同样可以通过 CD2 或 2B4 触发信号。 CD48 与 CD2 的相互作用提倡 T 细胞活化和 B 细胞中 IgG2a 的类别替代。 此外，CD48 对 2B4 的高亲和力，相互作用可以促进或抑制 NK 细胞以及细胞毒性 T 细胞活化。 CD48 不包含跨膜结构域，尽管它由 GPI 锚通过 C 端结构域保持在细胞表面，该 C 端结构域可能分裂以产生可溶形式的受体。

CD48 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 203 amino acids and having a molecular mass of 23.4kDa .
CD48 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 昆虫细胞中产生的 CD48 Human Recombinant 是单条糖基化多肽链，包含 203 个氨基酸，分子量为 23.4kDa。
CD48 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Sf9, Insect cells.

Greater than 90.0% as determined by -PAGE.

NECTIN2 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

ADPQGHLVHM TVVSGSNVTL NISESLPENY KQLTWFYTFD QKIVEWDSRK SKYFESKFKG RVRLDPQSGA LYISKVQKED NSTYIMRVLK KTGNEQEWKI KLQVLDPVPK PVIKIEKIED MDDNCYLKLS CVIPGESVNY TWYGDKRPFP KELQNSVLET TLMPHNYSRC YTCQVSNSVS
SKNGTVCLSP PCTLARSHHH HHH.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.