ProSpec,MDC Rat,巨噬细胞衍生的趋化因子大鼠重组CHM-279

C-C motif chemokine 22, Small-inducible cytokine A22, Macrophage-derived chemokine, MDC, Stimulated T-cell chemotactic protein 1, CC chemokine STCP-1, CCL22, MDC, SCYA22, ABCD-1, DC/B-CK, MGC34554, A-152E5.1, CC chemokine ABCD-1, Activated B and dendritic cell-derived, DCBCK.

MDC是属于CC趋化因子家族的小细胞因子。 CCL22 是聚集在 16 号染色体 q 臂上的几个 Cys-Cys 细胞因子基因之一。
MDC 对自然杀伤细胞、慢性活化的 T 淋巴细胞、单核细胞和树突状细胞具有趋化活性。另一方面，MDC 对原代活化的 T 淋巴细胞表现出温和的活性，对中性粒细胞、嗜酸性粒细胞和静息 T 淋巴细胞没有趋化活性。 MDC 还可能在活化 T 淋巴细胞向炎症部位的运输和活化 T 淋巴细胞生理学的其他方面发挥作用。 MDC 与细胞表面趋化因子受体 CCR4 相互作用。
CCL22 在巨噬细胞和单核细胞衍生的树突细胞和胸腺中大量表达。 CCL22 也存在于淋巴结、阑尾、活化的单核细胞、静息和活化的巨噬细胞中。 CCL22在肺和脾中的表达较低，在小肠中表达非常弱。在淋巴结中，CCL22 在成熟的朗格汉斯细胞亚群中表达。
此外，CCL22 在表皮和真皮的特应性皮炎、过敏性接触性皮炎皮肤和牛皮癣中均有表达。此外，MDC 具有阻碍肺癌进展的作用。此外，显着更高的 CCL22 表达与胃癌有关。

CCL22 Rat Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7.9kDa.
The Rat CCL22 is purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered White lyophilized powder.

The protein was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH7.4.

It is recommended to reconstitute the lyophilized MDC in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized MDC although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution MDC should be stored at 4C between 2-7 days and for future use below -18C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 97.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

GPYGANVEDS ICCQDYIRHP LPPRFVKEFY WTSKSCRKPG VVLITIKNRD ICADPRMLWV KKILHKLA.

Determined by its ability to chemoattract human activated lymphocytes using a concentration range of 10.0-100.0 ng/ml.

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.