CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets.PF4’s major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Furthermore, it is used as an inhibitor in the angiogenesis during tumor therapy.
血小板因子 4 是一种 70 个氨基酸的蛋白质，从活化的血小板的 α 颗粒中释放出来。PF4 的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部抗凝血酶 III 活性并促进凝血 . 作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化因子家族的成员。 此外，它还用作肿瘤治疗期间血管生成的抑制剂。
Platelet Factor-4 Bovine Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 88 amino acid and having a molecular mass of approximately 9.5kDa.
PF4 is purified by proprietary chromatographic techniques.
Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB and 500mM NaCl, pH 7.0.
It is recommended to reconstitute the lyophilized Platelet Factor-4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Lyophilized CXCL4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Platelet Factor-4 should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.
Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.
Amino acid sequence
ESSFPATFVP LPADSEGGED EDLQCVCLKT TSGINPRHIS SLEVIGAGTH CPSPQLLATK KTGRKICLDQ QRPLYKKILK KLLDGDES.
The biological activity determined by a chemotaxis bioassay using human neutrophils is 10-100ng/ml.
PF 4 Protein
PF 4 Human
CXCL4 Variant 1 Human
PF4 Human, His
PF 4 Mouse