ProSpec,Rantes Mouse CHM-342,Rantes 小鼠重组CHM-342

  • Rantes Mouse

  • Rantes Mouse Recombinant
  • CHM-342

Catalogue number

CHM-342

Synonyms

Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164.

Introduction

Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer cells to form CHAK cells. It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.
受激活、正常 T 细胞表达和分泌或 RANTES 的调节是一种 8 kDa 蛋白质,归类为趋化细胞因子或趋化因子。 它最近已更名为 CCL5。 RANTES 对 T 细胞、嗜酸性粒细胞和嗜碱性粒细胞具有趋化作用,并在将白细胞募集到炎症部位方面发挥积极作用。 在 T 细胞释放的特定细胞因子的帮助下,RANTES 还诱导某些自然杀伤细胞的增殖和活化,形成 CHAK 细胞。 它也是一种从 CD8+ T 细胞释放的 HIV 抑制因子。 这种趋化因子已定位于人类的第 17 号染色体。

Description

Rantes Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7876 Dalton.

The Mouse Rantes is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 Rantes Mouse Recombinant 是一个单一的、非糖基化的多肽链,含有 68 个氨基酸,分子量为 7876 道尔顿。

Mouse Rantes 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Lyophilized from a concentrated solution in water containing no additives.  

Solubility

It is recommended to reconstitute the lyophilized Rantes in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Mouse Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 Mouse Rantes 虽然在室温下可稳定保存 3 周,但应在 -18°C 以下干燥储存。 重组后,小鼠 CCL5 应在 4°C 下储存 2-7 天,以备将来在 -18°C 以下使用。
对于长期储存,建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS.

Biological Activity

The activity is determined by the ability to chemoattract total human lymphocytes and murine T-cells at a concentration between 1-10ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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