ProSpec,Rantes Rhesus Macaque,Rantes恒河猴重组体CHM-033

  • Rantes Rhesus Macaque

  • Rantes Rhesus Macaque Recombinant
  • CHM-033

Catalogue number

CHM-033

Synonyms

C-C motif chemokine 5, Small-inducible cytokine A5, T-cell-specific protein RANTES, CCL5.

Introduction

Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer cells to form CHAK cells. It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.
受激活、正常 T 细胞表达和分泌或 RANTES 的调节是一种 8 kDa 蛋白质,归类为趋化细胞因子或趋化因子。 它最近已更名为 CCL5。 RANTES 对 T 细胞、嗜酸性粒细胞和嗜碱性粒细胞具有趋化作用,并在将白细胞募集到炎症部位方面发挥积极作用。 在 T 细胞释放的特定细胞因子的帮助下,RANTES 还诱导某些自然杀伤细胞的增殖和活化,形成 CHAK 细胞。 它也是一种从 CD8+ T 细胞释放的 HIV 抑制因子。 这种趋化因子已定位于人类的第 17 号染色体。

Description

Rantes Rhesus Macaque Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 68 amino acids and having a molecular mass of 7.8kDa.
The CCL5 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered White lyophilized powder.

Formulation

Rantes protein was lyophilized from a 0.2µm filtered concentrated solution in 20mM PB pH 6.0 and 500mM NaCl.

Solubility

It is recommended to reconstitute the lyophilized Rantes in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability

Lyophilized Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
冻干的 Rantes 虽然在室温下可稳定保存 3 周,但应在 -18°C 以下干燥储存。 复溶后,CCL5 应在 4°C 下储存 2-7 天,以备将来在 -18°C 以下使用。
对于长期储存,建议添加载体蛋白。
请防止冻融循环。

Purity

Greater than 98.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Amino acid sequence

SPHASDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS.

Biological Activity

The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 1.0-10 ng/ml.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Prospec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

Related Products

  • Rantes Human, His
  • Rantes Mouse
  • Rantes Human
  • Rantes Rat