ProSpec-TARC Human His,胸腺和活化调节的趋化因子人重组CHM-359

  • TARC Human, His

  • Thymus and Activation Regulated Chemokine Human Recombinant , His Tag
  • CHM-359

Catalogue number



C-C motif chemokine 17, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CC chemokine TARC, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E5.3, MGC138271, MGC138273.


TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. Along with CC chemokine family members, CCL-17 has approximately 24-29% amino acid sequence identity with RANTES, MIP-1a, MIP-1b, MCP-1, MCP-2, MCP-3 and I-309. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
TARC cDNA 编码一个 94 个氨基酸的前体蛋白和一个 23 个氨基酸残基的信号肽,该信号肽被切割掉以产生 71 个氨基酸残基的成熟分泌蛋白。与 CC 趋化因子家族成员一起,CCL-17 与 RANTES、MIP-1a、MIP-1b、MCP-1、MCP-2、MCP-3 和 I-309 具有大约 24-29% 的氨基酸序列同一性。 TARC 在胸腺中表达,在肺、结肠和小肠中表达水平较低。此外,TARC 在受刺激的外周血单核细胞中瞬时表达。重组 TARC 已被证明对 T 细胞系具有趋化性,但对单核细胞或中性粒细胞没有。 CCL-17 最近被确定为 CCR4 的特异性功能配体,CCR4 是一种选择性表达于 T 细胞上的受体。 CCL17 是聚集在 16 号染色体 q 臂上的大量 Cys-Cys 细胞因子基因之一。CCL17 对 T 淋巴细胞显示趋化活性,但对单核细胞或粒细胞没有趋化活性。 CCL17 与趋化因子受体 CCR4 和 CCR8 结合。这种趋化因子在胸腺 T 细胞发育以及成熟 T 细胞的运输和激活中起重要作用。


TARC Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 92 amino acids and having a molecular mass of 10.3 kDa.
The TARC is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 TARC 人重组体是一种非糖基化的多肽链,含有 92 个氨基酸,分子量为 10.3 kDa。
TARC 在 N 末端与 20 个氨基酸 His-Tag 融合,并通过专有色谱技术进行纯化。


Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.


The TARC protein contains 1xPBS and 10% glycerol.


Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.


Greater than 95% as determined by Analysis by -PAGE.

Amino acid sequence



ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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