- Description
Catalogue number
CYT-241
Synonyms
Introduction
Vascular endothelial growth factor is an important signaling protein involved in vessel formation As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types . VEGF mediates increased vascular permeability, induces vasculogenesis and endothelial cell production, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor. VEGF is located in normal cartilage though only osteoarthritic cartilage expresses the VEGF receptors, NP1, VEGFR1 and VEGFR2. The VEGF level in the culture media from OA chondrocytes was more than 3 folds higher than in media from normal chondrocytes
Description
The VEGF is purified by proprietary chromatographic techniques.
Source
Physical Appearance
Formulation
Solubility
Stability
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
Purity
Analysis by RP-HPLC.
Analysis by -PAGE.
Amino acid sequence
Biological Activity
Protein content
1. UV spectroscopy at 280 nm using the absorbency value of 0.2875 as the extinction coefficient for a 0.1% solution. This value is calculated by the PC GENE computer analysis program of protein sequences .
2. Analysis by RP-HPLC, using a calibrated solution of VEGF as a Reference Standard.
Usage
References
1. Title:Expression of VEGF and Its Receptors in the Bovine Endometrium Throughout the Estrous Cycle: Effects of VEGF on Prostaglandin Production in Endometrial Cells.
Publication:Journal of Reproduction and Development
Vol. 56 No. 2 April P 223-229
Link:https://www.jstage.jst.go.jp/article/jrd/56/2/56_09-139S/_article
2.
Publications: Gene therapy 15.1 : 12-17.
Link: http://www.nature.com/gt/journal/v15/n1/full/3303035a.html
Publication: Cancer biology & therapy 10.7 : 703-711.
Link: http://www.tandfonline.com/doi/full/10.4161/cbt.10.7.12904
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