ProSpec-BAFF Human/CYT-307

BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNFSF13B, B-cell Activating Factor.

BAFF binds to tnfrsf13b/taci and tnfrsf17/bcma. Tnfsf13/april binds to the same 2 receptors, together, they form a 2 ligands -2 receptors pathway involved in the stimulation of b- and t-cell function and the regulation of humoral immunity. A third b-cell specific baff-receptor promotes the survival of mature b-cells and the b-cell response.
B Lymphocyte Stimulator functions as a potent B-cell growth factor in costimulation assays.
Administration of BAFF Human recombinant to mice disrupts splenic B-cell and T-cell zones and results in elevated levels of serum immunoglobulin.

BAFF 与 tnfrsf13b/taci 和 tnfrsf17/bcma 结合。 Tnfsf13/april与相同的2个受体结合，共同形成2个配体-2受体通路，参与刺激b细胞和t细胞功能以及调节体液免疫。 第三种 b 细胞特异性 baff 受体促进成熟 b 细胞的存活和 b 细胞反应。
B 淋巴细胞刺激剂在共刺激试验中用作有效的 B 细胞生长因子。
给小鼠施用 BAFF Human 重组体会破坏脾 B 细胞和 T 细胞区域，并导致血清免疫球蛋白水平升高。

BAFF Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17007 Dalton.
The BAFF is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 BAFF Human Recombinant 是单一的非糖基化多肽链，包含 153 个氨基酸，分子量为 17007 道尔顿。
BAFF 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.0.

It is recommended to reconstitute the lyophilized BAFF in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议将冻干的 BAFF 溶解在不低于 100µg/ml 的无菌 18M-cm H2O 中，然后可以进一步稀释成其他水溶液。

Lyophilized BAFF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BAFF should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

冻干 BAFF 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后 BAFF 应在 4°C 下储存 2-7 天，以备将来在低于 -18°C 的温度下使用。
请防止冻融循环。

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL.

The activity is determined by a mouse splenocyte survival assay. The ED₅₀ for this effect is 0.5-2.0µg/ml.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。