ProSpec-BAFF R Human/CYT-429

TNFRSF13C, CD268, BAFF-R, MGC138235, B cell-activating factor receptor.

B cell-activating factor enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus . Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

B 细胞激活因子可提高 B 细胞的体外存活率，并且是外周 B 细胞群的调节剂。 Baff 在小鼠中的过度表达导致成熟的 B 细胞增生和系统性红斑狼疮的症状。 此外，一些 SLE 患者的血清中 BAFF 水平升高。 因此，有人提出异常高水平的 BAFF 可能通过提高自身反应性 B 细胞的存活率而促成自身免疫性疾病的发病机制。 该基因编码的蛋白质是 BAFF 的受体，是一种 III 型跨膜蛋白，含有一个胞外富含半胱氨酸的结构域。 认为该受体是 BAFF 介导的成熟 B 细胞存活所需的主要受体。

B Lymphocyte Stimulator Receptor Human Recombinant extracellular produced in E.Coli is a single, non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 7.7 kDa.
The BAFF-R is purified by proprietary chromatographic techniques.

B 淋巴细胞刺激受体人重组细胞外在大肠杆菌中产生是一种单一的、非糖基化的多肽链，含有 76 个氨基酸，分子量为 7.7 kDa。
BAFF-R 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a 0.2μm filtered concentrated solution in 20mM PB, pH 8.0, 500mM NaCl.

It is recommended to reconstitute the lyophilized B Lymphocyte Stimulator Receptor Recombinant in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶冻干的 B 淋巴细胞刺激受体重组体，然后可以进一步稀释成其他水溶液。

Lyophilized BAFF-R although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution B Lymphocyte Stimulator Receptor should be stored at 4°C between 2-7 days and for future use below -18°C.
Please prevent freeze-thaw cycles.

冻干的 BAFF-R 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，B 淋巴细胞刺激器受体应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
请防止冻融循环。

MRRGPRSLRGRDAPAPTPCVPAECFDLLVRHCVACGLLRTPRPKPAG
ASSPAPRTALQPQESVGAGAGEAALPLPG.

Greater than 95.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED₅₀ for this effect is 1.0-5.0 µg/ml in the presence of 1.0µg/ml of human soluble BAFF.

由其阻断 BAFF 诱导的小鼠脾细胞存活的能力决定。 在 1.0 µg/ml 人可溶性 BAFF 存在下，这种效果的预期 ED50 为 1.0-5.0 µg/ml。

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。