ProSpec-BMP 7 Human, HEK/CYT-082,Bone Morphogenetic protein-7 Human Recombinant, HEK

Osteogenic Protein 1, BMP-7.

The bone morphogenetic proteins are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.

骨形态发生蛋白是可诱导异位骨生长的分泌型信号分子家族。 许多 BMP 是转化生长因子-β 超家族的一部分。 BMP 最初是通过脱矿质骨提取物在骨骼外部位诱导体内软骨内成骨的能力来鉴定的。 基于其在胚胎发生早期的表达，由该基因编码的 BMP 在早期发育中具有拟议的作用。 此外，这种 BMP 与 BMP5 和 BMP7 密切相关的事实已导致推测可能的骨诱导活性。

BMP-7 Human Recombinant produced in HEK cells is a glycosylated disulfide-linked homodimer, having a molecular weight range of 30-38kDa due to glycosylation.
The BMP7 corresponds to amino acid residues 315 to 431 of the full-length BMP-7 precursor and is purified by proprietary chromatographic techniques.

在 HEK 细胞中产生的 BMP-7 Human Recombinant 是一种糖基化的二硫键连接的同型二聚体，由于糖基化，其分子量范围为 30-38kDa。
BMP7 对应于全长 BMP-7 前体的 315 至 431 位氨基酸残基，并通过专有色谱技术进行纯化。

HEK.

Sterile Filtered White lyophilized powder.

The BMP7 was lyophilized from 1mg/ml in 1xPBS.

It is recommended to reconstitute the lyophilized BMP-7 in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议将冻干的 BMP-7 溶解在不低于 100 µg/ml 的无菌水中，然后可以进一步稀释成其他水溶液。

Lyophilized BMP7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP-7 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 BMP7 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，BMP-7 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 95% as obsereved by -PAGE.

The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line and is typically 50-250ng/ml.

DFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAM AVEEGGGPGGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPR YHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLDSRTLWASE EGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKAT.

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