ProSpec-BMP13 Human/CYT-938,Bone Morphogenetic protein-13 Human Recombinant

Growth Differentiation Factor 6, Growth/Differentiation Factor 16, Bone Morphogenetic Protein 13, BMP-13, BMP13, GDF-6, Klippel-Feil Malformation, Segmentation Syndrome 1, Klip-Feil Malformation, Klippel-Feil Syndrome, MCOPCB6, SCDO4, CDMP2, LCA17, MCOP4, GDF16, KFS1, KFSL, SGM1, KFM, KFS, GDF6.

生长分化因子 6、生长/分化因子 16、骨形态发生蛋白 13、BMP-13、BMP13、GDF-6、Klippel-Feil 畸形、分割综合征 1、Klip-Feil 畸形、Klippel-Feil 综合征、MCOPCB6、SCDO4、CDMP2 、LCA17、MCOP4、GDF16、KFS1、KFSL、SGM1、KFM、KFS、GDF6。

Growth/differentiation factors belong to the BMP family of TGF-beta superfamily proteins. These factors are produced as inactive preproproteins which are subsequently cleaved and assembled into active secreted homodimers. BMP13 is a growth factor which controls proliferation and cellular differentiation in the retina and bone formation. BMP13 has a central role in regulating apoptosis during retinal development. GDF proteins are vital during embryonic development, particularly in the skeletal, nervous, and muscular systems. BMP13 gene mutations result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome , which is a congenital disorder of spinal segmentation.

生长/分化因子属于 TGF-β 超家族蛋白的 BMP 家族。 这些因子作为无活性的前原蛋白产生，随后被切割并组装成有活性的分泌同源二聚体。 BMP13 是一种生长因子，可控制视网膜和骨形成中的增殖和细胞分化。 BMP13 在视网膜发育过程中在调节细胞凋亡中起核心作用。 GDF 蛋白在胚胎发育过程中至关重要，特别是在骨骼、神经和肌肉系统中。 BMP13 基因突变导致先天性眼发育异常的 colobomata 和先天性脊柱分割障碍 Klippel-Feil 综合征。

BMP13 Human Recombinant produced in E.coli is a non-glycosylated disulfide linked homodimer containing 2 chains of 120 amino acids and having a molecular mass of 27.1kDa.
The BMP-13 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 BMP13 Human Recombinant 是一种非糖基化二硫键连接的同型二聚体，含有 2 条 120 个氨基酸的链，分子量为 27.1kDa。
BMP-13 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

It is recommended to reconstitute the lyophilized BMP13 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 18M-cm H2O 中复溶冻干的 BMP13，然后可以进一步稀释成其他水溶液。

Lyophilized BMP13 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP-13 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 BMP13 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，BMP-13 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

The ED₅₀ as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 2.0µg/ml, corresponding to a specific activity of > 500IU/mg.

通过诱导小鼠 ATDC5 细胞产生碱性磷酸酶测定的 ED50 小于 2.0μg/ml，对应于 > 500IU/mg 的比活性。

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 它们不得用作药物、农业或农药产品、食品添加剂或家用化学品。