ProSpec-BMPR1A Human/CYT-380,Bone Morphogenetic Protein Receptor Type IA Human Recombinant

BMPR-1A, BMP-R1A, BMPR1A, BMR1A, CD292, CD-292, Serine/threonine-protein kinase receptor R5, SKR5, ALK-3, ACVRLK3, EC 2.7.11.30, CD292 antigen.

BMPR-1A、BMP-R1A、BMPR1A、BMR1A、CD292、CD-292、丝氨酸/苏氨酸蛋白激酶受体 R5、SKR5、ALK-3、ACVRLK3、EC 2.7.11.30、CD292 抗原。

The bone morphogenetic protein receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas transduce their signals through the formation of heteromeric complexes with 2 different types of serine kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

骨形态发生蛋白受体是一个跨膜丝氨酸/苏氨酸激酶家族，包括 I 型受体 BMPR1A 和 BMPR1B 以及 II 型受体 BMPR2。 这些受体也与受体 ACVR1 和 ACVR2 密切相关。 这些受体的配体是 TGF-β 超家族的成员。 TGF-β 通过与 2 种不同类型的丝氨酸激酶受体形成异聚复合物来转导其信号：约 50-55 kD 的 I 型受体和约 70-80 kD 的 II 型受体。 II 型受体在没有 I 型受体的情况下结合配体，但它们需要各自的 I 型受体进行信号传导，而 I 型受体需要各自的 II 型受体进行配体结合。

BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, Polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa.
The BMR1A is purified by proprietary chromatographic techniques.

在杆状病毒中产生的 BMPR1A 人重组细胞外结构域是在 C 端与 6xHis 标签融合的单体糖基化多肽链，分子量为 23 kDa。
BMR1A 通过专有的色谱技术进行纯化。

Insect Cells.

Sterile Filtered White lyophilized powder.

CD292 was lyophilized from a concentrated sterile solution containing 1X PBS.

It is recommended to reconstitute the lyophilized ALK-3 in sterile PBS not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

建议将冻干的 ALK-3 用不低于 100 µg/ml 的无菌 PBS 复溶，然后可以进一步稀释成其他水溶液。

Lyophilized Bone Morphogenetic Protein Receptor 1A although stable at room temperature for 3 weeks, should be stored desiccated below
-18°C. Upon reconstitution BMPR1A should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干骨形态发生蛋白受体 1A 虽然在室温下可稳定保存 3 周，但应在下面干燥保存
-18°C。 重组后，BMPR1A 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 90.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

Measured by its ability to inhibit recombinant human BMP-2 induced alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 1-3 µg/ml in the presence of 500 ng/ml of recombinant human BMP-2 corresponding to a Specific Activity of 2,000 units/mg.

通过其抑制重组人 BMP-2 诱导的 C2C12 肌原细胞产生碱性磷酸酶的能力来衡量。 在 500 ng/ml 重组人 BMP-2 的存在下，这种效果的 ED50 通常为 1-3 µg/ml，对应于 2,000 单位/mg 的比活性。

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。