ProSpec-BMPR1A Human, CHO/CYT-1094,Bone Morphogenetic Protein Receptor-1A Human Recombinant, CHO

BMPR-1A, BMP-R1A, BMPR1A, BMR1A, CD292, CD-292, Serine/threonine-protein kinase receptor R5, SKR5, ALK-3, ACVRLK3, EC 2.7.11.30, CD292 antigen.

The bone morphogenetic protein receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas transduce their signals through the formation of heteromeric complexes with 2 different types of serine kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

骨形态发生蛋白受体是一个跨膜丝氨酸/苏氨酸激酶家族，包括 I 型受体 BMPR1A 和 BMPR1B 以及 II 型受体 BMPR2。 这些受体也与受体 ACVR1 和 ACVR2 密切相关。 这些受体的配体是 TGF-β 超家族的成员。 TGF-β 通过与 2 种不同类型的丝氨酸激酶受体形成异聚复合物来转导其信号：约 50-55 kD 的 I 型受体和约 70-80 kD 的 II 型受体。 II 型受体在没有 I 型受体的情况下结合配体，但它们需要各自的 I 型受体进行信号传导，而 I 型受体需要各自的 II 型受体进行配体结合。

Bone Morphogenetic Protein Receptor-1A Human Recombinant produced in CHO cells is a glycosylated homodimer chain containing 2×362 amino acids and having a total molecular mass of 80.8kDa.

BMPR1A is purified by proprietary chromatographic techniques.

在 CHO 细胞中产生的 Bone Morphogenetic Protein Receptor-1A Human Recombinant 是一种糖基化同源二聚体链，含有 2×362 个氨基酸，总分子量为 80.8kDa。

BMPR1A 通过专有的色谱技术进行纯化。

CHO cells.

Sterile Filtered White lyophilized powder.

The protein was lyophilized from a sterile filtered solution containing PBS.

It is recommended to reconstitute the lyophilized BMPR1A in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized BMPR1A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMPR1A should be stored at 4°C between 2-7 days and for future use below -18°C.

冻干的 BMPR1A 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后，BMPR1A 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。

Please prevent freeze-thaw cycles.

QNLDSMLHGT GMKDQKK SENGVTLAPE DTLPFLKCYC SGHCPDDAIN NTCITNGHCF AIIEEDDQGE TTLASGCMKY EGSDFQCKDS PKAQLRRTIE CCRTNLCNQY LQPTLPPVVI GPFFDGSIRI EGRMDDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK.

Greater than 95.0% as determined by -PAGE.

The ED₅₀, as calculated by the Inhibition of human BMP-4-induced alkaline phosphatase production caused by ATDC5 cells is 120ng/ml corresponding to a specific activity of 8.3×10^3 units/mg.

通过抑制由 ATDC5 细胞引起的人 BMP-4 诱导的碱性磷酸酶产生来计算的 ED50 为 120ng/ml，对应于 8.3×10^3 单位/mg 的比活性。

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。