ProSpec-GDF15 D Human/CYT-314,Growth and Differentiation Factor 15 D-Variant Human Recombinant

GDF-15, MIC1, MIC-1, NAG-1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, Prostate differentiation factor, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, NRG-1, GDF15.

GDF-15、MIC1、MIC-1、NAG-1、PDF、PLAB、PTGFB、生长/分化因子 15、胎盘骨形态发生蛋白、胎盘 TGF-β、巨噬细胞抑制细胞因子 1、前列腺分化因子、NSAID 激活基因 1 蛋白、NSAID 调节基因 1 蛋白、NRG-1、GDF15。

GDF15 is part of the TGF-Beta superfamily that is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance.

GDF15 是 TGF-β 超家族的一部分，参与调节受损组织和整个疾病过程中的炎症和凋亡途径。 GDF15 在肝脏中含量最高。 在肝、肾、心、肺等器官损伤时，其在肝脏中的表达可显着上调。 由于细胞分化的差异，GDF-15 促进增殖或生长停滞和分化。 GDF15 通过激活 Akt 和抑制内源性活性 ERK 来防止小脑颗粒神经元的凋亡。 GDF15 是一种新型自分泌/内分泌因子，可拮抗肥厚反应和心室功能丧失。

GDF15 D-variant Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated, Polypeptide chain containing 2×113 amino acids and having a molecular mass of 24.5kDa.
The GDF15 D-variant is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 GDF15 D 变体人重组体是一种同源二聚体、非糖基化多肽链，含有 2×113 个氨基酸，分子量为 24.5kDa。
GDF15 D 变体通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

GDF15 D-variant is lyophilized without additives.

It is recommended to reconstitute the lyophilized GDF15 D-variant in sterile 5mM AcOH at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized GDF15 D-variant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF15 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 GDF15 D 变体虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，GDF15 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 95.0% as determined by
Analysis by RP-HPLC.
Analysis by -PAGE.

MARNGDDCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI.

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpecs 产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。