ProSpec-GDF15 Human, His/CYT-691,Growth and Differentiation Factor 15 Human Recombinant, His Tag

GDF-15, MIC1, MIC-1, NAG-1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, Prostate differentiation factor, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, NRG-1, GDF15.

GDF15 is part of the TGF-Beta superfamily that is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance.

GDF15 是 TGF-β 超家族的一部分，参与调节受损组织和整个疾病过程中的炎症和凋亡途径。 GDF15 在肝脏中含量最高。 在肝、肾、心、肺等器官损伤时，其在肝脏中的表达可显着上调。 由于细胞分化的差异，GDF-15 促进增殖或生长停滞和分化。 GDF15 通过激活 Akt 和抑制内源性活性 ERK 来防止小脑颗粒神经元的凋亡。 GDF15 是一种新型自分泌/内分泌因子，可拮抗肥厚反应和心室功能丧失。

Recombinant Human GDF15 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 151 amino acids and having a molecular mass of 16.7 kDa.
GDF15 is expressed with a 36 amino acid His tag fused at N-Terminus and purified by proprietary chromatographic techniques.

在大肠杆菌中产生的重组人 GDF15 是一条单一的、非糖基化的多肽链，含有 151 个氨基酸，分子量为 16.7 kDa。
GDF15 由在 N 末端融合的 36 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile filtered colorless solution.

The GDF15 protein solution contains 10mM sodium citrate, pH-3.5 & 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。
储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Greater than 95.0% as determined by -PAGE.

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.