ProSpec-Endoglin Human, His/CYT-823

Endoglin Human, His

Endoglin Human Recombinant, His-Tag
CYT-823
ProSpec-Endoglin Human, His/CYT-823 2µg
ProSpec-Endoglin Human, His/CYT-823 10µg
ProSpec-Endoglin Human, His/CYT-823 100µg

Catalogue number

CYT-823

Synonyms

CD105, ENG, END, ORW, HHT1, ORW1, FLJ41744, Endoglin.

Introduction

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.

The Endoglin protein consists of a homodimer of 180 kDA with disulfide links. Endoglin has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Endoglin has been found to be part of the TGF-beta1 receptor complex. Endoglin thus may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Endoglin expression is regulated during heart development . Experimental mice without the endoglin gene die due to cardiovascular abnormalities.

Endoglin 是一种位于细胞表面的 I 型膜糖蛋白，是 TGF β 受体复合物的一部分。
Endoglin 蛋白由具有二硫键的 180 kDA 同源二聚体组成。已在内皮细胞、活化的巨噬细胞、成纤维细胞和平滑肌细胞上发现内皮糖蛋白。此外，已发现内皮糖蛋白是 TGF-β1 受体复合物的一部分。因此，内皮糖蛋白可能参与 TGF-β1、TGF-β3、激活素 A、BMP-2 和 BMP-7 的结合。除了 TGF-β 信号转导内皮糖蛋白可能还有其他功能。据推测，内皮糖蛋白参与影响细胞形态和迁移的细胞骨架组织。 Endoglin 在心血管系统的发育和血管重塑中发挥作用。内皮糖蛋白的表达在心脏发育过程中受到调节。没有内皮糖蛋白基因的实验小鼠因心血管异常而死亡。

Description

Endoglin Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 594 amino acids and having a molecular mass of 64.9 kDa. Endoglin is fused to a 36 amino acid His-tag at N-terminus.

在大肠杆菌中产生的 Endoglin Human Recombinant 是一条含有 594 个氨基酸且分子量为 64.9 kDa 的单一非糖基化多肽链。 Endoglin 在 N 端与 36 个氨基酸的 His 标签融合。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

The Endoglin solution contains 20mM Tris-HCl buffer , 1mM DTT, 150mM NaCl and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 85% as determined by -PAGE.

Amino acid sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSETVH CDLQPVGPER DEVTYTTSQV SKGCVAQAPN AILEVHVLFL EFPTGPSQLE LTLQASKQNG TWPREVLLVL SVNSSVFLHL QALGIPLHLA YNSSLVTFQE PPGVNTTELP SFPKTQILEW AAERGPITSA AELNDPQSIL LRLGQAQGSL SFCMLEASQD MGRTLEWRPR TPALVRGCHL EGVAGHKEAH ILRVLPGHSA GPRTVTVKVE LSCAPGDLDA VLILQGPPYV SWLIDANHNM QIWTTGEYSF KIFPEKNIRG FKLPDTPQGL LGEARMLNAS IVASFVELPL ASIVSLHASS CGGRLQTSPA PIQTTPPKDT CSPELLMSLI QTKCADDAMT LVLKKELVAH LKCTITGLTF WDPSCEAEDR GDKFVLRSAY SSCGMQVSAS MISNEAVVNI LSSSSPQRKK VHCLNMDSLS FQLGLYLSPH FLQASNTIEP GQQSFVQVRV SPSVSEFLLQ LDSCHLDLGP EGGTVELIQG RAAKGNCVSL LSPSPEGDPR FSFLLHFYTV PIPKTGTLSC TVALRPKTGS QDQEVHRTVF MRLNIISPDL SGCTSKG

Usage

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.