ProSpec-EREG Human, His/CYT-859

Epiregulin, Proepiregulin, ER, ERP.

Epiregulin is part of the EGF family. Epiregulin functions as a ligand of EGFR, as well as a ligand of most members of the ERBB family of tyrosine-kinase receptors.Epiregulin is expressed mostly in the placenta and peripheral blood leukocytes and in specific carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. Epiregulin inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.

上皮调节蛋白是 EGF 家族的一部分。 上皮调节蛋白作为 EGFR 的配体，以及酪氨酸激酶受体 ERBB 家族大多数成员的配体。上皮调节蛋白主要在胎盘和外周血白细胞以及膀胱、肺、肾和结肠的特定癌中表达 . 上皮调节蛋白刺激角质形成细胞、肝细胞、成纤维细胞和血管平滑肌细胞的增殖。 Epiregulin 抑制几种肿瘤来源的上皮细胞系的生长。 人上皮调节蛋白最初合成为糖基化的 19.0 kDa 跨膜前体蛋白，通过蛋白水解切割加工产生 6.0 kDa 成熟分泌序列。

EREG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 69 amino acids and having a molecular mass of 7.7kDa.

Escherichia Coli.

Sterile Filtered colorless solution.

EREG protein solution containing 20mM Tris-HCl buffer and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Greater than 80.0% as determined by -PAGE

MGSSHHHHHH SSGLVPRGSH MGSVSITKCS SDMNGYCLHG QCIYLVDMSQ NYCRCEVGYT GVRCEHFFL.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.