ProSpec-TNFRSF10A Human/CYT-1043,TRAIL Receptor-1 Human Recombinant

TNFRSF10A Human

TRAIL Receptor-1 Human Recombinant
CYT-1043
2µg
10µg
1mg

Catalogue number

CYT-1043

Synonyms

TNFRSF10A, TNF Receptor Superfamily Member 10a, Tumor Necrosis Factor Receptor Superfamily, Member 10a, TNF-Related Apoptosis-Inducing Ligand Receptor 1, Death Receptor 4, TRAIL Receptor 1, TRAIL-R1, TRAILR1, APO2, DR4, Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2, Tumor Necrosis Factor Receptor Superfamily Member 10A, Cytotoxic TRAIL Receptor, CD261 Antigen, TRAILR-1, CD261.

Introduction

Human TNFRSF10A is a type 1 transmembrane protein in the TNF R superfamily. TNFRSF10A is not expressed in rodents. The trimeric ligand Trail binds TNFRSF10A and induces apoptosis, and recombinant, soluble forms of the receptor inhibit Trail-induced apoptosis. TNFRSF10A is expressed generally in damaged, infected, and malignant cells. TNFRSF10A functions in immune surveillance, inducing apoptosis in cancer cells but not normal cells.

人 TNFRSF10A 是 TNF R 超家族中的 1 型跨膜蛋白。 TNFRSF10A 在啮齿动物中不表达。三聚体配体 Trail 结合 TNFRSF10A 并诱导细胞凋亡，而重组的可溶性受体形式可抑制 Trail 诱导的细胞凋亡。 TNFRSF10A 通常在受损、感染和恶性细胞中表达。 TNFRSF10A 在免疫监视中起作用，诱导癌细胞而非正常细胞的凋亡。

Description

TNFRSF10A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 224 amino acids and having a molecular mass of 23.9kDa. TNFRSF10A is expressed with an 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 TNFRSF10A 是单条糖基化多肽链，包含 224 个氨基酸，分子量为 23.9kDa。 TNFRSF10A 在 C 末端带有 6 个氨基酸的 His 标签，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

TNFRSF10A protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。储存，在 -20°C 下冷冻更长时间。

对于长期储存，建议添加载体蛋白。

避免多次冻融循环。

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ASGTEAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARARAGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL HDQSIGTQQW EHSPLGELCP PGSHRSEHPG ACNRCTEGVG YTNASNNLFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CRKCSRGCPR GMVKVKDCTP WSDIECVHKE SGNGHNLEHH HHHH

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.