ProSpec-TNFR Human, His/CYT-673,Tumor Necrosis Factor Receptor Type Human Recombinant, His Tag

TNFR Human, His

Tumor Necrosis Factor Receptor Type Human Recombinant, His Tag
CYT-673
5µg
20µg
1mg

Catalogue number

CYT-673

Synonyms

Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, TNF-R1, TNF-RI, TNFR-I, p60, p55, CD120a, TNFRSF1A, TNFAR, TNFR1, FPF, TBP1, TNF-R, p55-R, TNFR55, TNFR60, TNF-R-I, TNF-R55, MGC19588.

Introduction

TNFR1 belongs to the TNF-receptor superfamily. TNFR1 is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha.
There are 2 types of soluble TNF receptors: sTNFR-I and sTNFR-II, which act to neutralize the biological activities of TNF alpha and TNF beta. The levels of these soluble receptors seem to increase as a result of shedding of the extracellular domains of the membrane bound receptors. TNF-a, TNFR1 and TNFR2 have roles in cellular differentiation. TNFR1 and TNFR2 function in cell type-specific renal injury.
TNFR1 is capable of signaling both cell survival and apoptosis. TNFR1-induced apoptosis requires 2 sequential signaling complexes. TNFR1 is capable of activating NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Oxidative stress promotes TNFR1 and TNFR2 self-interaction, ligand-independent and enhanced ligand-dependent TNF signaling. TNFR1 contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Human TNFR1 has a major region which controls cell surface expression. High levels of soluble TNF receptors are found in the amniotic fluid of pregnant women.
Germline mutations of the extracellular domains of TNFR1 are linked to the autosomal dominant periodic fever syndrome. The impaired receptor clearance is believed to be a mechanism of the disease. Familial hibernian fever is caused by defects in TNFRSF1A gene.
TNFR1 属于 TNF 受体超家族。 TNFR1 是 TNFSF2/TNF-α 和同源三聚体 TNFSF1/淋巴毒素-α 的受体。
有 2 种类型的可溶性 TNF 受体:sTNFR-I 和 sTNFR-II,它们起到中和 TNF α 和 TNF β 的生物活性的作用。这些可溶性受体的水平似乎由于膜结合受体的细胞外结构域脱落而增加。 TNF-α、TNFR1和TNFR2在细胞分化中起作用。 TNFR1 和 TNFR2 在细胞类型特异性肾损伤中起作用。
TNFR1 能够发出细胞存活和细胞凋亡的信号。 TNFR1 诱导的细胞凋亡需要 2 个连续的信号复合物。 TNFR1 能够激活 NF-kappaB,介导细胞凋亡,并起到炎症调节剂的作用。氧化应激促进 TNFR1 和 TNFR2 自我相互作用、配体非依赖性和增强的配体依赖性 TNF 信号传导。 TNFR1 有助于诱导非杀细胞性 TNF 效应,包括抗病毒状态和酸性鞘磷脂酶的激活。人 TNFR1 具有控制细胞表面表达的主要区域。在孕妇的羊水中发现了高水平的可溶性 TNF 受体。
TNFR1 细胞外结构域的种系突变与常染色体显性周期性发热综合征有关。受损的受体清除被认为是该疾病的一种机制。家族性冬眠热是由 TNFRSF1A 基因缺陷引起的。

Description

TNFR Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 161 amino acids fragment having a molecular weight of 22.68kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The TNFR His Tag is purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 TNFR Human Recombinant 是一个单一的、非糖基化的多肽链,包含 161 个氨基酸片段,分子量为 22.68kDa,并与 4.5kDa 氨基末端的六组氨酸标签融合。 TNFR His Tag 通过专有的色谱技术进行纯化。

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

TNFR His Tag protein is supplied in 1xPBS, 50% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

DSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQ
DTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVE
ISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCL
NGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKK
SLECTKLCLPQIEN.

References

Title: β-Catenin Signaling Pathway Is Crucial for Bone Morphogenetic Protein 2 to Induce New Bone Formation*

Publication: First Published on November 3, 2006, doi:10.1074/jbc.M602700200 January 5, 2007 The Journal of Biological Chemistry,282,526-533.
Link: http://www.jbc.org/content/282/1/526.full

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。

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