ProSpec-WISP2 Human/CYT-970

WNT1 Inducible Signaling Pathway Protein 2, Connective Tissue Growth Factor-Related Protein 58, Connective Tissue Growth Factor-Like Protein, CCN Family Member 5, CTGF-L, CT58, CCN5, WISP-2, CTGFL, WISP2.

WNT1-inducible-signaling pathway protein 2 belongs to the WNT1 inducible signaling pathway protein subfamily, which belongs to the connective tissue growth factor family. The CTGF family members are characterized by 4 conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP2 protein lacks the CT domain which is implicated in dimerization binding. WISP2 is possibly involved in bone remodeling. WISP2 is expressed in primary osteoblasts and fibroblasts. WISP2 stimulates osteoblast adhesion and inhibits osteocalcin production. WISP2 expression in colon tumors is reduced while the other 2 WISP members are overexpressed in colon tumors. WISP2 may play an imperative role in modulating bone turnover.

WNT1诱导信号通路蛋白2属于WNT1诱导信号通路蛋白亚家族，属于结缔组织生长因子家族。 CTGF 家族成员的特征在于 4 个保守的富含半胱氨酸结构域：胰岛素样生长因子结合结构域、von Willebrand 因子 C 型模块、血小板反应蛋白结构域和 C 末端胱氨酸结样结构域。 WISP2 蛋白缺乏与二聚化结合有关的 CT 结构域。 WISP2 可能参与骨重塑。 WISP2 在原代成骨细胞和成纤维细胞中表达。 WISP2 刺激成骨细胞粘附并抑制骨钙素的产生。 WISP2 在结肠肿瘤中的表达减少，而其他 2 个 WISP 成员在结肠肿瘤中过度表达。 WISP2 可能在调节骨转换中发挥重要作用。

WISP2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing a total of 228 amino acids and having a molecular mass of 24.4kDa.

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid .

It is recommended to reconstitute the lyophilized WISP-2 in sterile 10mM acetic acid not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized WISP2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution WISP-2 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 WISP2 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重构后，WISP-2 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 95.0% as determined by -PAGE.

MQLCPTPCTC PWPPPRCPLG VPLVLDGCGC CRVCARRLGE PCDQLHVCDA SQGLVCQPGA GPGGRGALCL LAEDDSSCEV NGRLYREGET FQPHCSIRCR CEDGGFTCVP LCSEDVRLPS WDCPHPRRVE VLGKCCPEWV CGQGGGLGTQ PLPAQGPQFS GLVSSLPPGV PCPEWSTAWG PCSTTCGLGM ATRVSNQNRF CRLETQRRLC LSRPCPPSRG RSPQNSAF.

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