ProSpec-CLCF1 Human/CYT-071

Cardiotrophin-like cytokine factor 1, B-cell-stimulating factor 3, BSF-3, Novel neurotrophin-1, NNT-1, CLCF1, BSF3, CLC, NNT1, NR6, CISS2.

Cardiotrophin-like cytokine factor 1 is a member of the interleukin 6 family of cytokines, which are involved in cell signaling via phosphorylation of gp130. CLCF1 has a sequence of 225 amino acids with a 27 aa signal peptide, having a molecular mass of 22kDa in the mature form, and the maximum homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 is actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in the CLCF1 gene cause cold-induced sweating syndrome 2 . The CISS2 syndrome is typified by profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine.

心肌营养素样细胞因子因子 1 是白细胞介素 6 细胞因子家族的成员，其通过 gp130 的磷酸化参与细胞信号传导。 CLCF1具有225个氨基酸的序列，带有27个氨基酸的信号肽，成熟形式的分子量为22kDa，与cardiotrophin-1和睫状神经营养因子同源性最大。 CLCF1 通过与可溶性 I 型 CRLF1 或可溶性 CNTFR 形成复合物从细胞中主动分泌。 CLCF1 基因的缺陷会导致感冒出汗综合征 2 。 CISS2综合征的典型特征是暴露于寒冷后大量出汗以及头部和脊柱的先天性身体异常。

CLCF1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 219 amino acids and having a molecular mass of 24.6kDa.
CLCF1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 CLCF1 Human Recombinant 是单条非糖基化多肽链，含有 219 个氨基酸，分子量为 24.6kDa。
CLCF1 在 N 端与 21 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered clear solution.

CLCF1 protein solution containing 20mM sodium citrate , 0.4M Urea and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Greater than 90% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF.

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.