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- TFA-Amino modifier CPG 500
TFA-Amino modifier CPG 500
| 货号 | 规格 | 价格 | 货期 |
|---|---|---|---|
| 11860 | 100 mg | 60.00$ | in stock |
| 21860 | 250 mg | 120.00$ | in stock |
| 31860 | 500 mg | 230.00$ | in stock |
| 41860 | 1 g | 380.00$ | in stock |
| 51860 | 5 g | 1450.00$ | 21 days |
| 61860 | 10 g | 2465.00$ | 21 days |
This high load, 500 Å controlled pore glass solid support is designed for the synthesis of oligonucleotides containing up to 50 bases with a 3′-amino group. Amino group is protected with trifluoroacetyl (TFA) protection which is easily removed under standard deblock conditions.
The reagent is based on hydroxyprolinol core – a universal non-nucleoside structure that is naturally 100% chiral (no isomers formed upon condensation), and stable to all conditions of oligonucleotide synthesis and deblock.
这种高负载、500 Å 可控孔玻璃固体支持物设计用于合成含有多达 50 个具有 3′-氨基的碱基的寡核苷酸。 氨基受到三氟乙酰 (TFA) 保护，在标准去封闭条件下可轻松去除。
该试剂基于羟基脯氨酸核心 – 一种通用的非核苷结构，天然 100% 手性（缩合时不形成异构体），并且对所有寡核苷酸合成和去封闭条件都稳定。
TFA-Amino modifier CPG 500相关产品
DMS(O)MT aminolink C6
An amidite for the introduction of amino group.
用于引入氨基的亚酰胺。
FAM Phosphoramidite, 6-Isomer
Single isomer 6-FAM phosphoramidite for the synthesis of modified oligonucleotides.
用于合成修饰寡核苷酸的单一异构体 6-FAM 亚磷酰胺。
DusQ2 dT phosphoramidite
General properties
| Appearance: | off-white beads |
| Quality control: | NMR 1H and HPLC-MS (95%) of bound reagent, loading measurement |
| Storage conditions: | Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
Oligo synthesis details
| Pore size, Å: | 500 |
| Typical loading, umol/g: | 50−80 |
| Coupling conditions: | standard coupling, identical to normal nucleobases |
| Cleavage conditions: | ammonia, 2 h at room temperature |
| Deprotection conditions: | identical to protected nucleobases |
相关文献：
- Taskova, M.; Uhd, J.; Miotke, L.; Kubit, M.; Bell, J.; Ji, H.P.; Astakhova, K. Tandem Oligonucleotide Probe Annealing and Elongation To Discriminate Viral Sequence. Analytical Chemistry, 2017, 89(8), 4363–4366. doi: 10.1021/acs.analchem.7b00646