ProSpec-APOA5 Human, HEK/CYT-025

Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3, APOA5, RAP3, APOAV.

ApoA5 is an important regulator of serum triglyceride concentrations. An ApoA5 mouse nock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. Furthermore, peroxisome proliferators-activated receptoragonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. There is very little known about ApoA5 protein in human serum. Lately, it was established that ApoA5 is present in the human serum and it can be detected by polyclonal antibodies against both the HN2 and COOH termini, but at much lower concentration than other apolipoproteins.

ApoA5 是血清甘油三酯浓度的重要调节剂。 ApoA5 小鼠敲除模型产生的血清甘油三酯增加约四倍，而敲入模型人 ApoA5 产生的小鼠血清甘油三酯浓度降低了 50-70%。 此外，临床上用于降低血清甘油三酯浓度的过氧化物酶体增殖物激活的受体激动剂会导致 ApoA5 mRNA 表达增加。 关于人血清中的 ApoA5 蛋白知之甚少。 最近，已确定 ApoA5 存在于人血清中，并且可以通过针对 HN2 和 COOH 末端的多克隆抗体检测到，但浓度远低于其他载脂蛋白。

APOA5 Human Recombinant Flag-Tagged Fusion Protein is 40.1 kDa protein containing 354 amino acid residues of the APOA5 Human and 11 additional amino acid residues of flagTag.

APOA5 Human Recombinant Flag-Tagged Fusion Protein 是一种 40.1 kDa 的蛋白质，含有 APOA5 Human 的 354 个氨基酸残基和 flagTag 的另外 11 个氨基酸残基。

HEK293

Filtered White lyophilized powder.

APOA5 Human was filtered and lyophilized from 0.5 mg/ml supplied in 20mM TRIS and 50mM NaCl, pH 7.5

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.

建议加入去离子水配制约 0.5mg/ml 的工作原液，让冻干颗粒完全溶解。 产品不是无菌的！ 在用于细胞培养之前，请用适当的无菌过滤器过滤产品。

Store lyophilized APOA5 Human at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted APOA5 Human can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

将冻干的 APOA5 Human 储存在 -20°C。 重组后分装产品以避免重复的冷冻/解冻循环。 重构的 APOA5 Human 可以在 4°C 下储存一段有限的时间； 在 4°C 下两周后它没有显示任何变化。

Greater than 70% as determined by -PAGE.

RKGFWDYFSQ TSGDKGRVEQ IHQQKMAREP ATLKDSLEQD LNNMNKFLEK LRPLSGSEAP RLPQDPVGMR RQLQEELEEV KARLQPYMAE AHELVGWNLE GLRQQLKPYT MDLMEQVALR VQELQEQLRV VGEDTKAQLL GGVDEAWALL QGLQSRVVHH TGRFKELFHP YAESLVSGIG RHVQELHRSV APHAPASPAR LSRCVQVLSR KLTLKAKALH ARIQQNLDQL REELSRAFAG TGTEEGAGPD PQMLSEEVRQ RLQAFRQDTY LQIAAFTRAI DQETEEVQQQ LAPPPPGHSA FAPEFQQTDS GKVLSKLQAR LDDLWEDITH SLHDQGHSHL GDPAAADYKD DDDK

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。