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- Alkyne CPG modifier 500
Alkyne CPG modifier 500
| 货号 | 规格 | 价格 | 货期 |
|---|---|---|---|
| 12860 | 100 mg | 60.00$ | in stock |
| 22860 | 250 mg | 120.00$ | in stock |
| 32860 | 500 mg | 230.00$ | in stock |
| 42860 | 1 g | 380.00$ | in stock |
| 52860 | 5 g | 1450.00$ | in stock |
High loading controlled pore glass solid support for the synthesis of oligonucleotides with 3′-alkyne group. With this solid support, synthesis of oligos of up to 50 bases is possible.
Terminal alkyne group can be modified by copper catalyzed Click chemistry (see our recommended protocol for oligonucleotide modification).
This solid support is compatible with standard oligonucleotide deblocking conditions. No special deblocking is required.
用于合成具有 3′-炔基的寡核苷酸的高负载可控孔玻璃固体支持物。 使用这种固体支持物，可以合成多达 50 个碱基的寡核苷酸。
末端炔基可以通过铜催化的点击化学进行修饰（参见我们推荐的寡核苷酸修饰方案）。
这种固体支持物与标准的寡核苷酸去封闭条件兼容。 不需要特殊的解块。
Alkyne CPG modifier 500相关产品
Pyrene phosphoramidite dU
Pyrene phosphoramidite with pyrene attached to deoxyuridine.
芘与脱氧尿苷相连的芘亚磷酰胺。
Alkyne Phosphoramidite, 5′-terminal
Alkyne phosphoramidite for the synthesis of oligonucleotides ready for Click chemistry.
用于合成寡核苷酸的炔亚磷酰胺，可用于点击化学。
FAM-dT phosphoramidite
Phosphoramidite for synthesis of oligonucleotides labeled with fluorescein (FAM) in the middle of sequence.
亚磷酰胺用于合成在序列中间用荧光素 (FAM) 标记的寡核苷酸。
General properties
| Appearance: | off-white beads |
| Quality control: | NMR 1H and HPLC (95%) of bound reagent, loading measurement |
| Storage conditions: | Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.
储存：-20°C 收货后 24 个月。 运输：在室温下长达 3 周。 干燥。 |
| MSDS: | Download |
| Product specifications |
Oligo synthesis details
| Pore size, Å: | 500 |
| Typical loading, umol/g: | 70−90 |
| Coupling conditions: | standard coupling, identical to normal nucleobases |
| Cleavage conditions: | ammonia, 2 h at room temperature |
| Deprotection conditions: | identical to protected nucleobases |
相关文献：
- Petrunina, N.A.; Lebedev, V.V.; Kirillova, Y.G.; Aralov, A..V.; Varizhuk, A.M.; Sardushkin, M.V. DNA Intercalated Motifs with Non-Nucleoside Inserts. Russian Journal of Bioorganic Chemistry, 2021, 47(6), 1341–1344. doi: 10.1134/S1068162021060212
- Svetlova, J.; Sardushkin, M.; Kolganova, N.; Timofeev, E. Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core. Biomolecules, 2021, 11(9), 1332. doi: 10.3390/biom11091332