Alkyne NHS ester (hexynoic acid NHS ester)

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  • Alkyne NHS ester (hexynoic acid NHS ester)

Alkyne NHS ester (hexynoic acid NHS ester)

标签:NHS esters, Alkynes, Protein labeling, Cross linking reagents
货号 规格 价格 货期
41720 25 mg 95.00$ in stock
51720 50 mg 195.00$ in stock
61720 100 mg 290.00$ in stock
91720 1 g please inquire in stock

Alkyne NHS ester for the modification of biomolecules. Alkyne groups for copper catalyzed Click Chemistry reaction are nearly never encountered in natural molecules. However, this NHS ester allows to attach alkyne groups to amino groups, which are ubiquitous in nature, and which are present in proteins, peptides, synthetic amino-DNA and numerous small molecules. Alkyne groups can be subsequently modified and conjugated by Copper catalyzed Click chemistry.

This reagent is a derivative of hexynoic acid.

用于生物分子修饰的炔烃 NHS 酯。 用于铜催化点击化学反应的炔基在天然分子中几乎从未遇到过。 然而,这种 NHS 酯允许将炔基连接到氨基上,氨基在自然界中普遍存在,并且存在于蛋白质、肽、合成氨基 DNA 和许多小分子中。 随后可以通过铜催化的点击化学修饰和缀合炔基。


Alkyne NHS ester (hexynoic acid NHS ester)相关产品

EdU (5-ethynyl-2′-deoxyuridine)

EdU is a nucleoside which is incorporated into replicated DNA by cellular enzymes. After it, DNA contained in the cells can be developed by Click chemistry reaction with fluorescent dye azides to reveal cell proliferation.

EdU 是一种核苷,可通过细胞酶掺入复制的 DNA 中。 之后,细胞中所含的 DNA 可以通过与荧光染料叠氮化物的 Click 化学反应进行显色,以揭示细胞增殖情况。

AF488 NHS ester

AF488 NHS ester, a bright, photostable and hydrophilic fluorescent dye for green channel.

AF488 NHS 酯,一种用于绿色通道的明亮、光稳定性和亲水性荧光染料。

Pyrenebutyric acid NHS ester

Pyrene NHS ester for the labeling of biomolecules with pyrene residue. Pyrene is a fluorescent proximity probe which forms excimers, and it is also an anchor group for graphite immobilization.

芘 NHS 酯,用于用芘残基标记生物分子。 芘是一种形成准分子的荧光邻近探针,也是石墨固定的锚定基团。

General properties

Appearance: yellowish oil / off white crystals 淡黄色油状物/类白色结晶
Mass spec M+ increment: 94.0
Molecular weight: 209.20
CAS number: 906564-59-8
Molecular formula: C10H11NO4
IUPAC name: 5-​Hexynoic acid, 2,​5-​dioxo-​1-​pyrrolidinyl ester
Solubility: good in organic solvents (DMF, DMSO, DCM)
Quality control: NMR 1H 95+%
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

储存:收到后 12 个月,在 -20°C 避光保存。 运输:在室温下长达 3 周。 避免长时间暴露在光线下。 干燥。

MSDS: Download
Product specifications


  1. Zanon, P.R.A.; Yu, F.; Musacchio, P.; Lewald, L.; Zollo, M.; Krauskopf, K.; Mrdović, D.; Raunft, P.; Maher, T.E.; Cigler, M.; Chang, C.; Lang, K.; Toste, F.D.; Nesvizhskii, A.I.; Hacker, S.M. Profiling the proteome-wide selectivity of diverse electrophiles. ChemRxiv, preprint. doi: 10.33774/chemrxiv-2021-w7rss-v2
  2. Kleinpenning, F.; Steigenberger, B.; Wu, W.; Heck, A.J.R. Fishing for newly synthesized proteins with phosphonate-handles. Nature Communications, 2020, 11, 3244. doi: 10.1038/s41467-020-17010-0