Application: IP, IF, WB, IHC(f)
Reactivity: Rabbit, Bovine, Human
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituents of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are heterotrimers composed of 3 non-identical chains that adopt a cruciform structure with 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene and in some cases undergoes alternative splicing to give rise to separate chain variants.
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