Anti Achaete-Scute Homolog 2 (ASH-2/MASH-2) pAb (Rabbit, Antiserum),CAC-SK-T01-004

Application: WB, IHC, IP

Clonality: Polyclonal

Host: Rabbit

Purification: Serum

Reactivity: Human, Mouse

Component of the Set-2/Ash-2 histone methyltransferase (HMT) complex. Required for di- and trimethylation at Lys-4 of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as a transcriptional regulator. Acts in the germline to limit soma longevity, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids.