Application: WB, IHC, IP
Reactivity: Human, Mouse
Component of the Set-2/Ash-2 histone methyltransferase (HMT) complex. Required for di- and trimethylation at Lys-4 of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as a transcriptional regulator. Acts in the germline to limit soma longevity, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids.