ProSpec,CD1A Human PRO-2427,CD1A人重组PRO-2427

T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, R4, T6; CD1, FCB6, HTA1, CD1A.

CD1a is a transmembrane glycoproteins, which is structurally related to the major histocompatibility complex proteins and form heterodimers with beta-2-microglobulin. CD1a mediates the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

CD1a是一种跨膜糖蛋白，在结构上与主要的组织相容性复合物蛋白相关，并与β-2-微球蛋白形成异二聚体。 CD1a 主要介导自身或微生物来源的脂质和糖脂抗原向 T 细胞的呈递。 人类基因组包含五个 CD1 家族基因，这些基因在 1 号染色体上组成一个簇。CD1 家族成员被认为在其细胞定位和对特定脂质配体的特异性方面不同。 该基因编码的蛋白质定位于质膜和早期内吞系统的循环囊泡。 已观察到选择性剪接的转录变体，但尚未确定其生物学有效性。

CD1A produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 291 amino acids and having a molecular mass of 33.2kDa. . CD1A is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD1A 是单条糖基化多肽链，含有 291 个氨基酸，分子量为 33.2kDa。 . CD1A 在 C 末端用 9 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Sf9, Baculovirus cells.

Sterile Filtered colorless solution.

CD1A protein solution containing Phosphate Buffered Saline , and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 85% as determined by -PAGE.

ADPDGLKEPL SFHVTWIASF YNHSWKQNLV SGWLSDLQTH TWDSNSSTIV FLCPWSRGNF SNEEWKELET LFRIRTIRSF EGIRRYAHEL QFEYPFEIQV TGGCELHSGK VSGSFLQLAY QGSDFVSFQN NSWLPYPVAG NMAKHFCKVL NQNQHENDIT HNLLSDTCPR FILGLLDAGK AHLQRQVKPE AWLSHGPSPG PGHLQLVCHV SGFYPKPVWV MWMRGEQEQQ GTQRGDILPS ADGTWYLRAT LEVAAGEAAD LSCRVKHSSL EGQDIVLYWE HHSSVHHHHH H.

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