ProSpec,CD247 Human,CD247 人重组PRO-1335

  • CD247 Human

  • CD247 Human Recombinant
  • PRO-1335

Catalogue number

PRO-1335

Synonyms

T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD247, CD3Z, T3Z, TCRZ, CD3H, CD3Q, CD3-ZETA.

Introduction

T-cell surface glycoprotein CD3 zeta chain is a member of the CD3Z/FCER1G family. CD247 is T-cell receptor zeta, which along with T-cell receptor alpha/beta and gamma/delta heterodimers, and also with CD3-gamma, -delta and -epsilon, creates the T-cell receptor-CD3 complex. The zeta chain has a central role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD247 antigen causes impaired immune response.
T 细胞表面糖蛋白 CD3 zeta 链是 CD3Z/FCER1G 家族的成员。 CD247 是 T 细胞受体 zeta,它与 T 细胞受体 α/β 和 γ/δ 异二聚体以及 CD3-γ、-δ 和 -epsilon 一起产生 T 细胞受体-CD3 复合物。 zeta 链在将抗原识别与几种细胞内信号转导途径偶联方面具有核心作用。 CD247 抗原的低表达导致免疫反应受损。

Description

CD247 Human Recombinant produced in E. coli is a single polypeptide chain containing 136 amino acids and having a molecular mass of 15.4kDa.
CD247 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CD247 solution contains 20mM Tris-HCl buffer , 0.15M NaCl, 10% glycerol and 1mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用,请在 4°C 下储存。 储存,在 -20°C 下冷冻更长时间。
对于长期储存,建议添加载体蛋白。
避免多次冻融循环。

Purity

Greater than 90% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MGSRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG KPQRRKNPQE GLYNELQKDK MAEAYSEIGM KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPR.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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