ProSpec,CD40 Mouse,CD40 小鼠重组PRO-2242

CD40 Mouse
CD40 Mouse Recombinant
PRO-2242
2µg

10µg

1mg

Catalogue number

PRO-2242

Synonyms

Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CD40.

Introduction

CD40 belongs to the TNF-receptor super family. CD40 has been found to be vital in mediating a wide range of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is accounted to coordinately regulate the expression of CD40 and its ligand, which is significant for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and functions as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be essential for amyloid-beta-induced microglial activation, and therefore is considered to be an early event in Alzheimer disease pathogenesis.

CD40 属于 TNF 受体超级家族。已发现 CD40 在介导广泛的免疫和炎症反应中至关重要，包括 T 细胞依赖性免疫球蛋白类别转换、记忆 B 细胞发育和生发中心形成。 AT-hook 转录因子 AKNA 可协调调节 CD40 及其配体的表达，这对同型细胞相互作用具有重要意义。衔接蛋白 TNFR2 与 CD40 相互作用并充当信号转导的介质。发现 CD40 与其配体的相互作用对于淀粉样蛋白-β 诱导的小胶质细胞活化至关重要，因此被认为是阿尔茨海默病发病机制的早期事件。

Description

CD40 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 180 amino acids and having a molecular mass of 20.1kDa .

CD40 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD40 是单条糖基化多肽链，含有 180 个氨基酸，分子量为 20.1kDa。
CD40 在 C 末端用 6 个氨基酸的 His 标签表达，并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

CD40 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

For long term storage it is recommended to add a carrier protein .

Avoid multiple freeze-thaw cycles.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。储存，在 -20°C 下冷冻更长时间。

对于长期储存，建议添加载体蛋白。

避免多次冻融循环。

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

LGQCVTCSDK QYLHDGQCCD LCQPGSRLTS HCTALEKTQC HPCDSGEFSA QWNREIRCHQ HRHCEPNQGL RVKKEGTAES DTVCTCKEGQ HCTSKDCEAC AQHTPCIPGF GVMEMATETT DTVCHPCPVG FFSNQSSLFE KCYPWTSCED KNLEVLQKGT SQTNVICGLK SRMRHHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

CD40 Mouse