ProSpec,CD47 Human,CD47人重组PRO-2237

  • CD47 Human

  • CD47 Human Recombinant
  • PRO-2237

Catalogue number

PRO-2237

Synonyms

CD47 Molecule, Antigenic Surface Determinant Protein OA3, CD47 Antigen , Antigen Identified By Monoclonal Antibody 1D8, Integrin Associated Protein, Integrin-Associated Protein, Rh-Related Antigen, CD47 Glycoprotein, MER6, IAP, Integrin-Associated Signal Transducer, Leukocyte Surface Antigen CD47, CD47 Antigen, Protein MER6, OA3, CD47.
CD47 分子、抗原性表面决定蛋白 OA3、CD47 抗原、由单克隆抗体 1D8 鉴定的抗原、整合素相关蛋白、整合素相关蛋白、Rh 相关抗原、CD47 糖蛋白、MER6、IAP、整合素相关信号转导子、白细胞表面抗原 CD47 、CD47 抗原、蛋白 MER6、OA3、CD47。

Introduction

CD47, functions in cell adhesions by performing as an adhesion receptor for THBS1 on platelets, furthermore CD47 plays a role in the modulation of integrins. In addition, CD47 takes a vital part in memory formation as well as synaptic plasticity in the hippocampus. Receptor for SIRPA avoids maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 prevents premature elimination of red blood cells, and it is also implicated in membrane permeability changes induced following virus infection.
CD47 通过作为血小板上 THBS1 的粘附受体在细胞粘附中发挥作用,此外 CD47 在整联蛋白的调节中起作用。 此外,CD47 在海马的记忆形成和突触可塑性中起着至关重要的作用。 SIRPA 受体可避免未成熟树突细胞成熟并抑制成熟树突细胞产生细胞因子。 CD47 可防止红细胞过早消除,并且它还与病毒感染后诱导的膜通透性变化有关。

Description

CD47 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain and fused to a 6 aa His Tag at C-terminus containing a total of 129 amino acids and having a molecular mass of 14.7kDa.
CD47 shows multiple bands between 18-28kDa on -PAGE, reducing conditions and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD47 是一条糖基化多肽链,在 C 端与一个 6 个氨基酸的 His 标签融合,共含有 129 个氨基酸,分子量为 14.7kDa。
CD47 在 -PAGE、还原条件和专有色谱技术纯化后显示 18-28kDa 之间的多个条带。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD47 protein solution contains Phosphate buffered saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by -PAGE.

Amino acid sequence

QLLFNKTKSV EFTFCNDTVV IPCFVTNMEA QNTTEVYVKW KFKGRDIYTF DGALNKSTVP TDFSSAKIEV SQLLKGDASL KMDKSDAVSH TGNYTCEVTE LTREGETIIE LKYRVVSWFS PNEHHHHHH.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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  • CD47 Human, IgG-His