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FCGR3A Human
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CD16a Human Recombinant
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PRO-1150
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Catalogue number
PRO-1150
Synonyms
Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma, RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, FCG3, FCGR3, IGFR3, CD16, FCGRIII.
Introduction
Low affinity immunoglobulin gamma Fc region receptor III-A is a receptor for the Fc portion of immunoglobulin G, and is involved in the elimination of antigen-antibody complexes from the circulation, as well as other antibody-dependent responses. FCGR3A needs to associate with the gamma subunit of Fc epsilon. The FCGR3A receptor is expressed on natural killer cells as an integral membrane glycoprotein anchored through a transmembrane peptide, while FCGR3B is expressed on polymorphonuclear neutrophils where the receptor is anchored through a phosphatidylinositol linkage. In addition, FCGR3A is expressed on macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. FCGR3A mediates antibody-dependent cellular cytotoxicity and other antibody-dependent responses, such as phagocytosis. FCGR3A gene mutations are linked with susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia.
低亲和力免疫球蛋白 γ Fc 区受体 III-A 是免疫球蛋白 G 的 Fc 部分的受体，参与从循环中消除抗原-抗体复合物以及其他抗体依赖性反应。 FCGR3A 需要与 Fc epsilon 的 γ 亚基结合。 FCGR3A 受体作为通过跨膜肽锚定的完整膜糖蛋白在自然杀伤细胞上表达，而 FCGR3B 在多形核中性粒细胞上表达，其中受体通过磷脂酰肌醇键锚定。 此外，FCGR3A 在巨噬细胞、T 细胞亚群、未成熟胸腺细胞和胎盘滋养细胞上表达。 FCGR3A 介导抗体依赖性细胞毒性和其他抗体依赖性反应，例如吞噬作用。 FCGR3A 基因突变与对复发性病毒感染的易感性、对系统性红斑狼疮的易感性和同种免疫新生儿中性粒细胞减少症有关。
Description
FCGR3A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 228 amino acids and having a molecular mass of 26kDa.
FCGR3A is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
FCGR3A is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
在大肠杆菌中产生的 FCGR3A 人重组体是一条单一的、非糖基化的多肽链，包含 228 个氨基酸，分子量为 26kDa。
FCGR3A 在 N 末端与 37 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。
FCGR3A 在 N 末端与 37 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。
Source
E.coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
FCGR3A protein solution containing 20mM Tris-HCl buffer , 1M Urea and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90% as determined by -PAGE.
Amino acid sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN VSSETVNITI TQGLAVSTIS SFFPPGYQ.
Usage
ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Related Products
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FCGR3A Human, Sf9