CD276 Mouse Recombinant
CD276 antigen, Cd276, 6030411F23Rik, AU016588, B7h3, B7RP-2, B7 homolog 3, B7-H3.
CD276, belongs to the B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. CD276 is a costimulatory molecule for T cell activation in addition to IFN-gamma production. Furthermore, CD276 upregulates BRCC3 expression, preventing DNA defects caused by 5-Fu. CD276 is correlated with TNM stage of NSCLC and act as a potential biomarker for NSCLC-derived MPEs. CD276 inhibits natural-killer mediated cell lysis in tumor cells, and act as a marker for detection of neuroblastoma cells. CD276 is implicated in the development of acute as well as chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. In addition, CD276 provides the placenta & fetus a proper immunological environment during the course of pregnancy.
CD276，属于 T 细胞表达的免疫调节性跨膜糖蛋白 B7 家族。 CD276 是除了 IFN-γ 产生之外的 T 细胞活化的共刺激分子。 此外，CD276 上调 BRCC3 表达，防止由 5-Fu 引起的 DNA 缺陷。 CD276 与 NSCLC 的 TNM 分期相关，可作为 NSCLC 衍生 MPE 的潜在生物标志物。 CD276 抑制肿瘤细胞中自然杀伤剂介导的细胞裂解，并作为检测神经母细胞瘤细胞的标志物。 CD276 与急性和慢性移植排斥的发展以及黏膜表面淋巴细胞活性的调节有关。 此外，CD276 在怀孕期间为胎盘和胎儿提供了适当的免疫环境。
CD276 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 226 amino acids and having a molecular mass of 24.7kDa.
CD276 is fused to a 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
CD276 protein solution contains Phosphate Buffered Saline containing 10% glycerol.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
Greater than 90.0% as determined by -PAGE.
Amino acid sequence
VEVQVSEDPV VALVDTDATL RCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FTEGRDQGSA
YSNRTALFPD LLVQGNASLR LQRVRVTDEG SYTCFVSIQD FDSAAVSLQV AAPYSKPSMT
LEPNKDLRPG NMVTITCSSY QGYPEAEVFW KDGQGVPLTG NVTTSQMANE RGLFDVHSVL
RVVLGANGTY SCLVRNPVLQ QDAHGSVTIT GQPLTFPPEA HHHHHH
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