ProSpec,CD160 Human,CD160 人重组PRO-2419

CD160 Molecule, CD160 Antigen, Natural Killer Cell Receptor BY55, BY55, Natural Killer Cell Receptor, Immunoglobulin Superfamily Member , CD160 Transmembrane Isoform, CD160-Delta Ig, NK28, NK1, CD160.

CD160 antigen is a human natural killer -cell-activating receptor which is also expressed on T-cell subsets. CD160 is a tumor-specific antigen known to mediate cellular activation signals in CLL, and is a novel target for therapeutic manipulation and monitoring of minimal residual disease. CD160 was identified as a T cell coinhibitory molecule which interacts with the herpesvirus entry mediator on antigen-presenting cells to deliver a potent inhibitory signal to CD4 T cells. CD160 expression is strongly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 has a broad specificity for binding to both classical and nonclassical MHC class I molecules.

CD160 抗原是一种人类自然杀伤细胞激活受体，它也在 T 细胞亚群上表达。 CD160 是一种已知在 CLL 中介导细胞激活信号的肿瘤特异性抗原，是治疗操作和监测微小残留疾病的新靶点。 CD160 被鉴定为 T 细胞共抑制分子，它与抗原呈递细胞上的疱疹病毒进入介质相互作用，向 CD4 T 细胞传递有效的抑制信号。 CD160 表达与具有溶细胞效应活性的外周血 NK 细胞和 CD8 T 淋巴细胞密切相关。 CD160 在所有肠上皮内淋巴细胞上都有表达。 CD160 对结合经典和非经典 MHC I 类分子具有广泛的特异性。

CD160 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 142 amino acids and having a molecular mass of 15.9kDa . CD160 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD160 Human Recombinant 是单条糖基化多肽链，包含 142 个氨基酸，分子量为 15.9kDa。 CD160 在 C 末端用 6 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Sf9, Baculovirus cells.

Sterile filtered colorless solution.

CD160 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 90.0% as determined by -PAGE.

ADLINITSSA SQEGTRLNLI CTVWHKKEEA EGFVVFLCKD RSGDCSPETS LKQLRLKRDP GIDGVGEISS QLMFTISQVT PLHSGTYQCC ARSQKSGIRL QGHFFSILFT ETGNYTVTGL KQRQHLEFSH NEGTLSHHHH HH.

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