ProSpec,CD163 Human,CD163 人重组PRO-2496

CD163 Molecule, Hemoglobin Scavenger Receptor, CD163 Antigen,  M130, Scavenger Receptor Cysteine-Rich Type 1 Protein M130, Macrophage-Associated Antigen, SCARI1,  MM130,CD163.

CD163 is an acute phase-regulated receptor which participates in the removal and endocytosis of hemoglobin/haptoglobin complexes by macrophages and thus keeps tissues from free hemoglobin-mediated oxidative damage. Furthermore, CD163 partakes in the uptake and recycling of iron, through endocytosis of hemoglobin/haptoglobin and ensuing breakdown of heme. In addition, CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent way. CD163 demonstrates greater affinity for complexes of hemoglobin and multimeric haptoglobin of HP-1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP-1S phenotype. Moreover, CD163 stimulates a cascade of intracellular signals which involves tyrosine kinase-dependent calcium recruitment, inositol triphosphate formation and secretion of IL-6 & CSF-1.

CD163 是一种急性期调节受体，它参与巨噬细胞对血红蛋白/触珠蛋白复合物的去除和内吞作用，从而使组织免受游离血红蛋白介导的氧化损伤。 此外，CD163 通过血红蛋白/触珠蛋白的内吞作用和随后的血红素分解参与铁的吸收和循环。 此外，CD163 以钙依赖性和 pH 依赖性方式结合血红蛋白/触珠蛋白复合物。 CD163 对 HP-1F 表型的血红蛋白和多聚触珠蛋白复合物的亲和力比对 HP-1S 表型的血红蛋白和二聚触珠蛋白复合物的亲和力更高。 此外，CD163 刺激一系列细胞内信号，包括酪氨酸激酶依赖性钙募集、三磷酸肌醇形成以及 IL-6 和 CSF-1 的分泌。

CD163 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 1015 amino acids and having a molecular mass of 109.8kDa. . CD163 is expressed with an 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD163 是单条糖基化多肽链，含有 1015 个氨基酸，分子量为 109.8kDa。 . CD163 在 C 末端以 6 个氨基酸 His 标签表达，并通过专有色谱技术进行纯化。

Sf9, Baculovirus cells.

Sterile Filtered colorless solution.

CD163 protein solution contains phosphate Buffered Saline .

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.

Greater than 90.0% as determined by -PAGE.

SSLGGTDKEL RLVDGENKCS GRVEVKVQEE WGTVCNNGWS MEAVSVICNQ LGCPTAIKAP GWANSSAGSG RIWMDHVSCR GNESALWDCK HDGWGKHSNC THQQDAGVTC SDGSNLEMRL TRGGNMCSGR IEIKFQGRWG TVCDDNFNID HASVICRQLE CGSAVSFSGS SNFGEGSGPI WFDDLICNGN ESALWNCKHQ GWGKHNCDHA EDAGVICSKG ADLSLRLVDG VTECSGRLEV RFQGEWGTIC DDGWDSYDAA VACKQLGCPT AVTAIGRVNA SKGFGHIWLD SVSCQGHEPA IWQCKHHEWG KHYCNHNEDA GVTCSDGSDL ELRLRGGGSR CAGTVEVEIQ RLLGKVCDRG WGLKEADVVC RQLGCGSALK TSYQVYSKIQ ATNTWLFLSS CNGNETSLWD CKNWQWGGLT CDHYEEAKIT CSAHREPRLV GGDIPCSGRV EVKHGDTWGS ICDSDFSLEA ASVLCRELQC GTVVSILGGA HFGEGNGQIW AEEFQCEGHE SHLSLCPVAP RPEGTCSHSR DVGVVCSRYT EIRLVNGKTP CEGRVELKTL GAWGSLCNSH WDIEDAHVLC QQLKCGVALS TPGGARFGKG NGQIWRHMFH CTGTEQHMGD CPVTALGASL CPSEQVASVI CSGNQSQTLS SCNSSSLGPT RPTIPEESAV ACIESGQLRL VNGGGRCAGR VEIYHEGSWG TICDDSWDLS DAHVVCRQLG CGEAINATGS AHFGEGTGPI WLDEMKCNGK ESRIWQCHSH GWGQQNCRHK EDAGVICSEF MSLRLTSEAS REACAGRLEV FYNGAWGTVG KSSMSETTVG VVCRQLGCAD KGKINPASLD KAMSIPMWVD NVQCPKGPDT LWQCPSSPWE KRLASPSEET WITCDNKIRL QEGPTSCSGR VEIWHGGSWG TVCDDSWDLD DAQVVCQQLG CGPALKAFKE AEFGQGTGPI WLNEVKCKGN ESSLWDCPAR RWGHSECGHK EDAAVNCTDI SVQKTPQKAT TGRSSRQSSH HHHHH

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