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CD19 Human
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CD19 Human Recombinant
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PRO-2552
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Catalogue number
PRO-2552
Synonyms
CD19 Molecule, B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12, Differentiation Antigen CD19, CD19 Antigen, B-Lymphocyte Antigen CD19, CVID3, B4.
Introduction
CD19, also known as B-Lymphocyte Surface Antigen B4, belongs to the Ig superfamily which is expressed on the surface of all B-lymphoid cells with the exception of terminally differentiated plasma cells. CD19 is involved as a signal-transducing receptor in the control of differentiation as well as proliferation. CD19 is as an adaptor protein which drafts cytoplasmic signaling proteins to the membrane and operates within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. CD19 is present on all B cells, and therefore is a biomarker for lymphoma diagnosis, B lymphocyte development and can be used as a target for leukemia immunotherapies.
CD19，也称为B淋巴细胞表面抗原B4，属于Ig超家族，在除终末分化浆细胞外的所有B淋巴细胞表面均有表达。 CD19 作为信号转导受体参与控制分化和增殖。 CD19 是一种衔接蛋白，可将细胞质信号蛋白引导至膜上，并在 CD19/CD21 复合物中发挥作用，以降低 B 细胞受体信号通路的阈值。 CD19 存在于所有 B 细胞上，因此是淋巴瘤诊断、B 淋巴细胞发育的生物标志物，可用作白血病免疫疗法的靶标。
Description
CD19 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 510 amino acids and having a molecular mass of 57.0kDa. .
CD19 is expressed with a 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
在 Sf9 杆状病毒细胞中产生的 CD19 是单条糖基化多肽链，含有 510 个氨基酸，分子量为 57.0kDa。 .
CD19 在 C 末端用 239 个氨基酸的 hIgG-His 标签表达，并通过专有色谱技术进行纯化。
Source
Physical Appearance
Formulation
CD19 protein solution contains Phosphate Buffered Saline and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Purity
Greater than 85.0% as determined by -PAGE.
Amino acid sequence
EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH