ProSpec,CD28 Human,CD28人重组PRO-2437

  • CD28 Human

  • CD28 Human Recombinant
  • PRO-2437

Catalogue number

PRO-2437

Synonyms

T-cell-specific surface glycoprotein CD28, TP44, CD_antigen: CD28, T-cell-specific surface glycoprotein CD28 isoform 1.

Introduction

CD28 co-stimulation is necessary for CD4 positive T-cell proliferation & survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence.

CD28 共刺激对于 CD4 阳性 T 细胞增殖和存活、白细胞介素 2 产生和 T 辅助 2 型发育是必需的。 人类胸腺后调节性 T 细胞需要 CD28 共刺激来扩展和维持体内有效的抑制功能。 细胞凋亡在与年龄相关的 CD28 表达下降和免疫衰老中起关键作用。

Description

CD28 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 376 amino acids and having a molecular mass of 42.4kDa . CD28 is expressed with a 242 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CD28 Human Recombinant 是单条糖基化多肽链,包含 376 个氨基酸,分子量为 42.4kDa。 CD28 在 C 末端用 242 个氨基酸的 hIgG-His 标签表达,并通过专有色谱技术进行纯化。

Source

Sf9, Baculovirus cells.

Physical Appearance

Sterile filtered colorless solution.

Formulation

CD28 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by -PAGE.

Amino acid sequence

ADPNKILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPLEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH.

Usage

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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