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CD40 Human, HEK
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CD40 Human Recombinant, HEK
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PRO-2719
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Catalogue number
PRO-2719
Synonyms
CD40 Molecule, TNF Receptor Superfamily Member 5, TNFRSF5, Tumor Necrosis Factor Receptor Superfamily, Member 5, Bp50, B-Cell Surface Antigen CD40, CD40L Receptor, CDW40, B Cell Surface Antigen CD40, B Cell-Associated Molecule, CD40 Antigen , CD40 Type II Isoform, Nerve Growth Factor Receptor-Related B-Lymphocyte Activation Molecule, p50, Tumor Necrosis Factor Receptor Superfamily Member 5, CDw40, CD40 Antigen
CD40 分子,TNF 受体超家族成员 5,TNFRSF5,肿瘤坏死因子受体超家族,成员 5,Bp50,B 细胞表面抗原 CD40,CD40L 受体,CDW40,B 细胞表面抗原 CD40,B 细胞相关分子,CD40 抗原,CD40 II 型同工型、神经生长因子受体相关 B 淋巴细胞激活分子、p50、肿瘤坏死因子受体超家族成员 5、CDw40、CD40 抗原
Introduction
CD40 belongs to the TNF-receptor super family. CD40 has been found to be vital in mediating a wide range of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is accounted to coordinately regulate the expression of CD40 and its ligand, which is significant for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and functions as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be essential for amyloid-beta-induced microglial activation, and therefore is considered to be an early event in Alzheimer disease pathogenesis.
CD40 属于 TNF 受体超级家族。 已发现 CD40 在介导广泛的免疫和炎症反应中至关重要,包括 T 细胞依赖性免疫球蛋白类别转换、记忆 B 细胞发育和生发中心形成。 AT-hook 转录因子 AKNA 可协调调节 CD40 及其配体的表达,这对同型细胞相互作用具有重要意义。 衔接蛋白 TNFR2 与 CD40 相互作用并充当信号转导的介质。 发现 CD40 与其配体的相互作用对于淀粉样蛋白-β 诱导的小胶质细胞活化至关重要,因此被认为是阿尔茨海默病发病机制的早期事件。
Description
CD40 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing 412 amino acids and having a molecular mass of 46.1kDa.
CD40 is expressed with a 239 amino acid hIgG-His-Tag at C-Terminus and purified by proprietary chromatographic techniques.
在 HEK 细胞中产生的 CD40 Human Recombinant 是单条糖基化多肽链,包含 412 个氨基酸,分子量为 46.1kDa。
CD40 在 C 末端用 239 个氨基酸的 hIgG-His-Tag 表达,并通过专有色谱技术进行纯化。
Source
HEK 293.
Physical Appearance
Sterile filtered colorless solution.
Formulation
CD40 protein solution contains 10% glycerol and Phosphate-Buffered Saline .
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.
Purity
Greater than 95.0% as determined by -PAGE.
Amino acid sequence
EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLRLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH
Usage
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