ProSpec-CXCL17 Human/CHM-019,VEGF 共调节趋化因子 1 人重组/CHM-019

VEGF coregulated chemokine 1, C-X-C motif chemokine 17, Dendritic cell and monocyte chemokine-like protein, DMC, CXCL17, VCC1, Dcip1, VCC-1, UNQ473.

树突状细胞和单核细胞趋化因子样蛋白是一种分泌型分子，其大小和预测的 3 维折叠模式类似于趋化因子 CXCL8/IL8 和 CXCL14/BRAK。 CXCL17 由气道和肠上皮组成性地产生。 CXCL17 诱导静止的、但不是 LPS 激活的外周血单核细胞和树突状细胞的趋化性，并且它还特异性地结合这些细胞。 当体外诱导形成管时，内皮细胞中CXCL17的表达增加。 在血管生成中起作用的CXCL17、CXCL1/GRO和CXCL8/IL8在原发性肺、乳腺和食管肿瘤中与VEGF的表达显着相关。 因此，CXCL17被认为在肿瘤血管生成中起作用。 成熟的大鼠 CXCL17 分别与小鼠、人 CXCL17 共享 82%、71% 的氨基酸序列同一性。

CXCL17 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 98 amino acids and having a molecular mass of 11.5kDa.
The CXCL17 is purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered White lyophilized powder.

CXCL17 protein was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4, containing 3% Trehalose.

It is recommended to reconstitute the lyophilized CXCL17 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

冻干的 CXCL17 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 重组后，CXCL17 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。 对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

SSLNPGVARG HRDRGQASRR WLQEGGQECE CKDWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVKKTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFALPL.

The ED₅₀ as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0µg/ml, corresponding to a specific activity of > 200IU/mg.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.