ProSpec-I 309 Human CHM-312,I-309 人类重组

Small inducible cytokine A1, CCL1, T lymphocyte-secreted protein I-309, chemokine ligand 1, P500, SISe, TCA3, I-309, SCYA1.

Chemokine ligand 1 is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.

趋化因子配体 1 是一种由活化的 T 细胞分泌的小糖蛋白，属于称为趋化因子的炎性细胞因子家族。 CCL1 通过与称为 CCR8 的细胞表面趋化因子受体相互作用来吸引单核细胞、NK 细胞、未成熟 B 细胞和树突状细胞。 这种趋化因子存在于人类 17 号染色体上的一大群 CC 趋化因子中。

I-309 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 74 amino acids and having a molecular mass of 8504 Dalton.
The I-309 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 I-309 Human Recombinant 是一种单一的、非糖基化的多肽链，含有 74 个氨基酸，分子量为 8504 道尔顿。
I-309 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

The CCL1 protein was lyophilized with no additives.

It is recommended to reconstitute the lyophilized I-309 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized I-309 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

Greater than 99.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Lys-Ser-Met-Gln.

The Biological activity is calculated by its ability to chemoattract human T cells at 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.