ProSpec,IP 10 Human His,CHM-346

Small inducible cytokine B10, CXCL10, 10 kDa interferon-gamma-induced protein, Gamma-IP10, IP-10, chemokine ligand 10, C7, IFI10, INP10, crg-2, mob-1, SCYB10, gIP-10.

Chemokine ligand 10 is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein . CXCL10 is secreted by several cell types in response to IFN-?. These cell types include monocytes, endothelial cellsand fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytesand T cells, promotion of T cell adhesion to endothelial cells, anti tumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

趋化因子配体 10 是一种小细胞因子，属于 CXC 趋化因子家族，也称为 10 kDa 干扰素-γ 诱导蛋白。 CXCL10 由几种细胞类型响应 IFN-α 分泌。 这些细胞类型包括单核细胞、内皮细胞和成纤维细胞。 CXCL10 具有多种作用，例如对单核细胞和 T 细胞的化学吸引、促进 T 细胞与内皮细胞的粘附、抗肿瘤活性以及抑制骨髓集落形成和血管生成。 CXCL10 基因位于人类第 4 号染色体上，与其他几种 CXC 趋化因子形成一个簇。 这种趋化因子通过与细胞表面趋化因子受体 CXCR3 结合来引发其作用。 该趋化因子的三维晶体结构已在 3 种不同条件下确定，分辨率高达 1.92A。

IP-10 His Tag Human Recombinant ?produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 77 amino acids fragment and having a total molecular mass of 8.5 kDa with an amino-terminal hexahistidine tag.
The IP-10 His is purified by proprietary chromatographic techniques.

IP-10 His Tag Human Recombinant ?在大肠杆菌中产生是单一的、非糖基化的多肽链，包含 77 个氨基酸片段，总分子量为 8.5 kDa，带有氨基末端的六组氨酸标签。
IP-10 His 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered clear solution.

IP-10 His is supplied in 10mM Tris HCl pH8, 1mM EDTA and 50% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
Please avoid freeze thaw cycles.

Greater than 95.0% as determined by Analysis by RP-HPLC.
Analysis by -PAGE.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.