PF 4 Human
Platelet Factor-4 Human Recombinant
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets. Its major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
血小板因子 4 是一种由 70 个氨基酸组成的蛋白质，由活化血小板的 α 颗粒释放。 它的主要生理作用似乎是中和血管内皮表面的分子，从而抑制局部抗凝血酶 III 活性并促进凝血。 作为中性粒细胞和成纤维细胞的强化学引诱剂，PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化因子家族的成员。 此外，它还用作肿瘤治疗期间血管生成的抑制剂。
The CXCL4 protein was filtered and lyophilized from a concentrated solution containing 20mM PB and 1.5M NaCl, pH 7.4.
It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.
Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.
Amino acid sequence
EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY
The biological activity determined by a chemotaxis bioassay using human fibroblasts is in a concentration of 1.0-10 ng/ml.
ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.
PF4 Human, His
PF 4 Protein
PF 4 Mouse
CXCL4 Variant 1 Human