ProSpec-PF4 Human His CHM-015,血小板因子 4 人重组CHM-015

  • PF4 Human, His

  • Platelet Factor-4 Human Recombinant , His Tag
  • CHM-015

Catalogue number

CHM-015

Synonyms

CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Introduction

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
血小板因子 4 是一种由 70 个氨基酸组成的蛋白质,它从活化的血小板的 α 颗粒中释放出来,并以高亲和力与肝素结合。 它的主要生理作用似乎是中和血管内皮表面的肝素样分子,从而抑制局部抗凝血酶 III 活性并促进凝血。 作为中性粒细胞和成纤维细胞的强化学引诱剂,PF4 可能在炎症和伤口修复中发挥作用。 Oncostatin-A 是 CXC 趋化因子家族的成员。 人 PF4 用于证明肝素诱导的血小板减少症。 此外,它还用作肿瘤治疗期间血管生成的抑制剂。

Description

PF4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 91 amino acids and having a molecular mass of 10kDa.
PF4 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless clear solution.

Formulation

PF4 protein solution contains 20mM Tris-HCl buffer , 0.2M NaCl, 50% glycerol and 2mM DTT.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Please avoid freeze thaw cycles.
如果整个小瓶将在 2-4 周内使用,请在 4°C 下储存。
储存,在 -20°C 下冷冻更长时间。
对于长期储存,建议添加载体蛋白。
请避免冻融循环。

Purity

Greater than 85.0% as determined by -PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MEAEEDGDLQ CLCVKTTSQV RPRHITSLEV IKAGPHCPTA QLIATLKNGR KICLDLQAPL YKKIIKKLLE S.

Usage

Prospec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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