Bedaquiline fumarate

Bedaquiline fumarate

Bedaquiline fumarate 贝达喹啉富马酸盐
分子式:C32H31BrN2O2.C4H4O4分子量:671.58

简介: Bedaquiline fumarate 是一种二芳基喹啉抗生素,能够作用于 ATP 合成酶,常用于治疗结核杆菌感染。
物理性状及指标:
外观:……………………粉末
溶解性:…………………DMSO:100 mg/mL (148.90 mM);Ethanol:4 mg/mL (5.96 mM);Water:Insoluble
含量:……………………>98%,BR
储存条件:-20°C,避光防潮密闭干燥

生物活性(仅来自于公开文献,不保证其有效性)

描述

Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.

体外

Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis.

储液配置及储存: 按表中溶解性配置;如溶解困难,可以通过快速搅拌,超声或温和加热(在45-60°C下水浴)。液体稳定性报道的很少,建议现配现用,如需储存,建议:-20℃1-3月;-80℃ 3-6月。

浓度/体积/质量

1 mg

5 mg

10 mg

1 mM

1.4890 mL

7.4451 mL

14.8903 mL

5 mM

0.2978 mL

1.4890 mL

2.9781 mL

10 mM

0.1489 mL

0.7445 mL

1.4890 mL

50 mM

0.0298 mL

0.1489 mL

0.2978 mL

【注意 】
●我司产品为非无菌包装,若用于细胞培养,请提前做预处理,除去热原细菌,否则会导致染菌。

●部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,以上数据仅供参考交流研究之用。

我司所售出产品仅供于科研研究用途(非临床科研研究),每次销售产品行为都适用于我司网上所列明的

CAS 号:845533-86-0
英文名字:贝达喹啉富马酸盐
质量标准:>98%,BR
分子式:C32H31BrN2O2.C4H4O4
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