细胞松弛素 H;Cytochalasin H
分子式:C30H39NO5, 分子量:493.6
物理性状及指标:
外观:……………………白色冻干粉
溶解性:…………………溶于DMSO、乙醇
炽灼残留:………………<0.1%
纯度:……………………>95%
生物活性:
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin H is a potent inhibitor of actin incorporation into filaments. Like cytochalasin D, it also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening. Cytochalasin H suppresses the production of reactive oxygen species by stimulated human neutrophils, blocks endocytosis of CD59 in lymphocytes, and shows anti-angiogenic activity both in vitro and in vivo细胞松弛素是抑制肌动蛋白聚合的细胞渗透性真菌代谢物。 这会干扰细胞运动、生长、吞噬作用、脱粒和分泌等多种过程。 Cytochalasin H 是肌动蛋白掺入细丝的有效抑制剂。 与细胞松弛素 D 一样,它也增加细丝的稳态扩散系数,表明它刺激细丝缩短。 Cytochalasin H 抑制受刺激的人中性粒细胞产生的活性氧,阻断淋巴细胞中 CD59 的内吞作用,并在体外和体内均显示出抗血管生成活性
用途及描述:科研试剂.
储存条件: -15~-20°C相关产品推荐:
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CAS 号:53760-19-3
英文名字:Cytochalasin H